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Rat IgG1 Isotype Control (BG Violet 450) [clone: HRPN]

Catalog Number: (75842-470)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The HRPN monoclonal antibody is used as an Isotype Control immunoglobulin for rat IgG1 antibodies.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.
Image Unavailable-75842-652

Anti-Foxp3 Rat Monoclonal Antibody (APC (Allophycocyanin)) [clone: MF23]

Catalog Number: (75842-652)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The MF23 monoclonal antibody specifically reacts with the mouse 50-55 kDa Foxp3 protein (JM2, IPEX), a member of the forkhead family of transcription factors. Foxp3 is expressed by the Treg lymphocytes, whose development and function are influenced by the forkhead protein. Ectopic expression of Foxp3 in T lymphocytes inhibits their activity and cytokine expression. Mutations of Foxp3 result in the “scurfy” mice phenotype. It is reported that the MF23 antibody recognizes an epitope between 1-87 amino acids in the N-terminal domain of mouse Foxp3.
Image Unavailable-75842-562

Anti-Ly-6G Rat Monoclonal Antibody (PE (Phycoerythrin)) [clone: RB6-8C5]

Catalog Number: (75842-562)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The RB6-8C5 monoclonal antibody reacts with the mouse Ly-6G (also known as Gr-1). The Ly-6G protein is a myeloid differentiation antigen of 21-25 kDa, expressed in a regulated manner by the myeloid lineage in the bone marrow, where the level of antigen expression is correlated with the granulocyte maturation and differentiation. In the bone marrow, the antigen is not expressed by the erythroid cells. From the peripheric cells, RB6-8C5 binds with monocytes, neutrophils and eosinophils.As a marker for the mouse monocytes, macrophages and granulocytes, the RB6-8C5 antibody is usually combined with M1/70, a macrophage labeling antibody (Anti-CD11b), for phenotypic analysis.
Image Unavailable-75842-598

Anti-Foxp3 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: 3G3]

Catalog Number: (75842-598)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The 3G3 monoclonal antibody specifically reacts with the mouse 50-55 kDa Foxp3 protein (JM2, IPEX), a member of the forkhead family of transcription factors. Foxp3 is expressed by the Treg lymphocytes, whose development and function are influenced by the forkhead protein. Ectopic expression of Foxp3 in T lymphocytes inhibits their activity and cytokine expression.Mutations of Foxp3 result in the “scurfy” mice phenotype.
Image Unavailable-75842-600

Anti-Foxp3 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: 3G3]

Catalog Number: (75842-600)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The 3G3 monoclonal antibody specifically reacts with the mouse 50-55 kDa Foxp3 protein (JM2, IPEX), a member of the forkhead family of transcription factors. Foxp3 is expressed by the Treg lymphocytes, whose development and function are influenced by the forkhead protein. Ectopic expression of Foxp3 in T lymphocytes inhibits their activity and cytokine expression.Mutations of Foxp3 result in the “scurfy” mice phenotype.
Image Unavailable-75842-782

Anti-CD90.2 Rat Monoclonal Antibody (BG Violet 450) [clone: 30-H12]

Catalog Number: (75842-782)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The 30-H12 monoclonal antibody specifically binds to MouseCD90.2, an alloantigen known as Thy-1.2, expressed on thymocytes, mature T cells, epithelial cells, neurons, hematopoietic stem cells, and fibroblasts. CD90 is a membrane glycoprotein that regulates the adhesion and signal transduction in T lymphocytes, and the adhesion of thymocytes to thymic stroma. The interaction between 30-H12 and the antibody to the CD3/TCR complex upregulates thymocytes signal transduction and apoptosis and downregulates mature T cell proliferation. The 30-H12 antibody seems to be unable to cross-link with CD90.1.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.
Image Unavailable-75842-792

Anti-CD11b (M1/70) Rat Monoclonal Antibody (PerCP (Peridinin-Chlorophyll Protein Complex)-Cy5.5®) [clone: M1/70]

Catalog Number: (75842-792)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The M1/70 monoclonal antibody specifically reacts with the 170 kDa αM integrin chain of mouse CD11b from the Mac-1 integrin (CD11b/CD18). Mac-1 binds to C3bi, CD54 (ICAM-1), and fibrinogen, and it is expressed by granulocytes, macrophages, NK cells, myeloid-derived dendritic cells, microglia, activated lymphocytes, and mouse B-1 cells. The expression is up-regulated on activated neutrophils at the same time that L-selectin is shed from the cell surface. The M1/70 antibody is used for the detection of monocytes, granulocytes, and a subset of natural killer cells in human peripheral blood.M1/70 blocks C3bi binding and cell adherence, but not cell-mediated lysis and it cross-reacts with human CD11b.
Image Unavailable-75842-828

Anti-CD11c Mouse Monoclonal Antibody (PE (Phycoerythrin)-Cy7®) [clone: 3.9]

Catalog Number: (75842-828)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The 3.9 monoclonal antibody specifically binds to the human adhesion glycoprotein CD11c, a 150 kDA integrin α chain also known as integrin alpha X. It is expressed on macrophages, granulocytes, monocytes, dendritic cells, natural killer cells, and subsets of B and T lymphocytes. The CD11c/CD18 complex associates with the iC3b, fibrinogen and ICAM-1 and has an important function in leukocyte adhesion.
Image Unavailable-75842-820

Anti-CD11c Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: 3.9]

Catalog Number: (75842-820)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The 3.9 monoclonal antibody specifically binds to the human adhesion glycoprotein CD11c, a 150 kDA integrin α chain also known as integrin alpha X. It is expressed on macrophages, granulocytes, monocytes, dendritic cells, natural killer cells, and subsets of B and T lymphocytes. The CD11c/CD18 complex associates with the iC3b, fibrinogen and ICAM-1 and has an important function in leukocyte adhesion.
Image Unavailable-75842-842

Anti-CD21 mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: HB5]

Catalog Number: (75842-842)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The HB5 monoclonal antibody specifically reacts with human CD21, a 145 kDA glycosylated type I integral membrane protein. CD21 is reported to be involved in B cell activation and proliferation. It is expressed on follicular dendritic cells, mature B cells, a subset of T cells, and a subset of epithelial cells. It is the receptor utilized by the Epstein-Barr virus to infect B cells.
Image Unavailable-75842-898

Anti-CD3 Rat Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: 17A2]

Catalog Number: (75842-898)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The 17A2 monoclonal antibody specifically reacts with the MouseT lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation. CD3 is expressed by thymocytes and mature lymphocytes, and contains γ, δ, and ε subunits, involved in the assembly, trafficking, and surface expression of T-cell receptor complex. The interaction between the T lymphocytes and the 17A2 antibody can be blocked by the 145-2C11 anti-CD3e antibody, demonstrating that the 17A2 antibody recognizes the CD3 ε chain. 
Image Unavailable-75842-838

Anti-CD21 mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: HB5]

Catalog Number: (75842-838)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The HB5 monoclonal antibody specifically reacts with human CD21, a 145 kDA glycosylated type I integral membrane protein. CD21 is reported to be involved in B cell activation and proliferation. It is expressed on follicular dendritic cells, mature B cells, a subset of T cells, and a subset of epithelial cells. It is the receptor utilized by the Epstein-Barr virus to infect B cells.
Image Unavailable-75843-084

Anti-CD8b Rat Monoclonal Antibody (APC (Allophycocyanin)) [clone: H35-17.2]

Catalog Number: (75843-084)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The H35-17.2 monoclonal antibody specifically reacts the mouse cd8 beta, a 32 kDa chain also known as Ly-3 and Lyt-3. CD8 is a T cell surface antigen co-receptor that interacts with MHC class I molecules on antigen presenting cells. It is expressed as a heterodimer with the alpha cd8 chain. The H35-17.2 antibody blocks T cell-mediated cytolysis of allogeneic lymphoma cells.
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Anti-CD5 Mouse Monoclonal Antibody (APC (Allophycocyanin)) [clone: UCHT2]

Catalog Number: (75843-038)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The UCHT2 monoclonal antibody specifically reacts with human CD5, a 67 kda type 1 transmembrane glycoprotein. CD5 is expressed on mature T cells, a subset of B cells, and peripheral blood dendritic cells. B cells that are CD5+ produce mostly IgM polyreactive antibodies. Its ligand is CD72, which is involved in T, B cell proliferation and interaction. The UCT2 antibody also recognizes non-human primate CD5.
Image Unavailable-75843-074

Anti-CD8a Mouse Monoclonal Antibody (APC (Allophycocyanin)-Cy7®) [clone: RPA-T8]

Catalog Number: (75843-074)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The RPA-T8 monoclonal antibody specifically reacts with the human CD8a molecule, a 32 kDa cell surface receptor expressed either as a heterodimer (CD8 α/β) or as a homodimer (CD8 α/α) on the majority of thymocytes, a subpopulation of mature T cells, and natural killer cells. CD8 interacts with the major histocompatibility complex class I (MHC class I) molecules on antigen-presenting cells or epithelial cells. The RPA-T8 antibody reacts with 13-48% of peripheral lymphocytes, 80% of thymocytes, and a subset of natural killer cells. RPA-T8, OKT8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitope or block each other by steric hindrance.
Image Unavailable-75843-034

Anti-CD5 Mouse Monoclonal Antibody (PerCP (Peridinin-Chlorophyll Protein Complex)-Cy5.5®) [clone: UCHT2]

Catalog Number: (75843-034)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The UCHT2 monoclonal antibody specifically reacts with human CD5, a 67 kda type 1 transmembrane glycoprotein. CD5 is expressed on mature T cells, a subset of B cells, and peripheral blood dendritic cells. B cells that are CD5+ produce mostly IgM polyreactive antibodies. Its ligand is CD72, which is involved in T, B cell proliferation and interaction. The UCT2 antibody also recognizes non-human primate CD5.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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