You Searched For: ADIPOGEN CORP MS

Catalog Number: (102515-164)

Supplier: Adipogen

Description: The transmembrane and secreted protein delta-like 1 homolog (DLK1; Protein delta homolog 1; Preadipocyte factor 1; Pref-1) belongs to the EGF-like family. It can be cleaved by a tumor necrosis factor-alpha converting enzyme (TACE) to release a soluble form. DLK1 plays important roles in regulating cell differentiation such as adipogenesis and osteogenesis. Membrane-bound DLK1 promotes hypertrophic myotube formation, whereas soluble DLK1 inhibits myotube formation. The soluble form of DLK1 inhibits preadipocyte differentiation, while membrane DLK1 represses preadipocyte proliferation. DLK1 is also associated with tumor invasion.

Supplier: Adipogen

Description: Calreticulin is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity. It constitutes together with calnexin and ERp57 the ‘calreticulin/calnexin cycle’ that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis.

Supplier: Adipogen

Description: CTRP5 (C1qTNF-related protein 5; C1QTNF5) belongs to a highly conserved family of adiponectin paralogs. CTRP5 mediates activation of AMP-activated protein kinase (AMPK) in muscle and liver cells, thereby regulating glucose and lipid metabolism. Serum levels of CTRP5 are significantly higher in obese/diabetic animal models compared to normal controls. Furthermore, CTRP5 may be a putative biomarker for mitochondrial dysfunction. Defects in C1QTNF5 are a cause of late-onset retinal degeneration (LORD).

Catalog Number: (102513-400)

Supplier: Adipogen

Description: CD4 binds to MHC Class II expressed by antigen presenting cells, facilitating T cell receptor signaling.

Catalog Number: (102513-374)

Supplier: Adipogen

Description: Human CD86 (B7-2) is a costimulating ligand for CD28 and CD152 (CTLA-4). CD86 is expressed on activated B cells and blood monocytes.

Catalog Number: (102513-382)

Supplier: Adipogen

Description: Human CD86 (B7-2) is a costimulating ligand for CD28 and CD152 (CTLA-4). CD86 is expressed on activated B cells and blood monocytes.

Catalog Number: (102513-404)

Supplier: Adipogen

Description: CD4 binds to MHC Class II expressed by antigen presenting cells, facilitating T cell receptor signaling.

Catalog Number: (102513-380)

Supplier: Adipogen

Description: Recombinant muIg control protein was engineered to be a negative control for muIg containing fusion proteins.

Catalog Number: (102512-638)

Supplier: Adipogen

Description: The cytokine human interferon-gamma (IFN-gamma) is a glycosylated protein that exists as a homodimer of 34kDa in its biologically active form. IFN-gamma is expressed upon activation by TH1 cells CD8+ cells and NK cells. Secreted IFN-gamma is a potent inhibitor of in vitro hematopoiesis and appears to serve as an important regulator of lymphocyte and macrophage function by exerting antiproliferative effects.

Catalog Number: (102512-648)

Supplier: Adipogen

Description: Human DR3 (TRAMP; LARD) was designated TNF receptor superfamily member 25. TL1A is a ligand which can induce apoptosis through a cytoplasmic death domain similar to the CD178-CD95 (FasL-Fas) interaction. Alternatively, engagement of DR3 on T cells can synergize with other activating signals to enhance IFNgamma production.

Catalog Number: (102512-578)

Supplier: Adipogen

Description: Human CD74 is expressed intracellularly and on the cell surface of MHC Class II positive cells such as B cells, monocytes, macrophages, Langerhans cells and dendritic cells. CD74 has several important functions relating to antigen presentation by MHC Class II molecules.

Catalog Number: (102512-576)

Supplier: Adipogen

Description: Human CD74 is expressed intracellularly and on the cell surface of MHC Class II positive cells such as B cells, monocytes, macrophages, Langerhans cells and dendritic cells. CD74 has several important functions relating to antigen presentation by MHC Class II molecules.

Catalog Number: (102512-610)

Supplier: Adipogen

Description: Human CD79a is a 22kDa glycoprotein which associates with CD79b to form a functional heterodimer that interacts with membrane immunoglobulin (mIg).The mIgM component binds antigen and the heterodimer transduces signals.

Supplier: Adipogen

Description: K-252a is an antibiotic, PKC, PKA and PKG inhibitor.

Catalog Number: (102511-356)

Supplier: Adipogen

Description: Interleukin-15 (IL-15) has a broad spectrum of biological activities. It is crucial for the development, proliferation, survival and differentiation of multiple cells from both innate and adaptive immune systems. IL-15 up-regulation has a central role in the development of several autoimmune or chronic inflammatory disorders. Targeting IL-15 or its receptor may have a valuable impact on the treatment of immune-mediated diseases. IL-15 participates in the development of important immune antitumor mechanisms. It activates CD8(+) T cells, natural killer (NK) cells, NK T cells, and can promote the formation of antitumor antibodies. IL-15 can also protect T effector cells from the action of T regulatory cells and reverse tolerance to tumor-associated antigens. In pre-clinical studies IL-15 has been found to demonstrate potentiated antitumor effects following pre-association with IL-15Ralpha, or when used in combination with chemotherapy, adoptive therapy, monoclonal antibodies, and tumor vaccines.

Catalog Number: (102511-322)

Supplier: Adipogen

Description: Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation and bone formation and regeneration. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMP-RIA or BMP-RIB) and a type II receptor (BMP-RII or Activin RIIB). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth and bone and cartilage repair. It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells and vascular smooth muscle cells. It also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells and is required for cardiac contractility.