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Anti-FLIP Monoclonal Antibody [clone: NF6]

Supplier: Adipogen
Description: FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes.

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Anti-IL-38 Monoclonal Antibody [clone: Nhat-1]

Catalog Number: (102971-630)
Supplier: Adipogen
Description: IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 as a IL-1 family receptor antagonist. Il-38 inhibits IL-36 signaling by binding to IL-1R6. IL-38 (aa 20-152) is released from apoptotic cells to limit inflammatory macrophage and downstream Th17 activation by blocking IL1RAPL1 (Interleukin-1 receptor accessory protein-like 1, TIGIRR-2) signaling. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.
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Anti-NOTCH1 Monoclonal Antibody (Biotin) [clone: No: (22E5)]

Catalog Number: (102971-576)
Supplier: Adipogen
Description: Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.
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EM574 ≥95% (by HPLC)

Supplier: Adipogen
Description: Shows strong gastrointestinal motor stimulating (GMS) activity. Motilin receptor agonist. Stimulates smooth muscle cell contraction. Stimulates cholinergic neurons in a non-vagal pathway. Enhances gastrointestinal contractile activity and accelerates gastric emptying. Shows orexigenic activity with affinity for the growth-hormone secretagogue receptor (GHS-R, ghrelin receptor).

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Forskolin ≥98% (by HPLC, TLC)

Supplier: Adipogen
Description: Potent, cell permeable adenylyl cyclase activator. Increases intracellular cAMP levels. Widely used tool to investigate cAMP as a second messenger. Inotropic and antihypertensive. Smooth muscle relaxant/vasodilator. Glucose transporter inhibitor. Platelet aggregation inhibitor. Stimulates lipolysis in fat cells. Non-competitive nicotinic acetylcholine receptors inhibitor. MAP kinase inhibitor. Upregulates mitochondrial uncoupling protein (UCP) mRNA levels in brown adipose tissue. Autophagy inhibitor. Hedgehog signaling inhibitor. Has antiglaucoma potential. Promotes neuronal differentiation of NSCs.

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Apicidin ≥98% (by HPLC, TLC)

Supplier: Adipogen
Description: Antiprotozoal. Potent inhibitor of histone deacetylase (HDAC). Inhibits proliferation. Induces cell cycle arrest at the G1 phase. Induces hyperacetylation of histone H4. Apoptosis inducer. Potent anti-angiogenic compound. Decreases HIF-1alpha protein levels and transcriptional activity in human and mouse tumor cell lines. Autophagy inducer in oral squamous cell carcinoma (OSCC) cells. Promotes either self-renewal or differentiation of embryonic stem cells.

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Amidepsine A ≥95% (by HPLC)

Supplier: Adipogen
Description: Diacylglycerol acyltransferase (DGAT) inhibitor. Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.

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Harzianum A ≥95% (by HPLC)

Supplier: Adipogen
Description: Antifungal. Anticancer compound. Cytotoxic to human cancer cell lines.

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N-Butanoyl-L-homoserine lactone ≥97%, white solid

Catalog Number: (102987-486)
Supplier: Adipogen
Description: N-Butanoyl-L-homoserine lactone, Purity: greater than or equal to 97% (GC), CAS Number: 67605-85-0, Formula: C8H13NO3, MW: 171.2, Solubility: Soluble in chloroform, Synonyms: N-(2-Oxotetrahydro-3-furanyl)butanamide, Appearance: White solid, Size: 10 mg
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N-Butanoyl-L-homoserine lactone ≥97% (by GC)

Catalog Number: (102987-488)
Supplier: Adipogen
Description: N-butyryl-L-Homoserine lactone is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones (AHL) are involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention, and formation of biofilms.
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FAMC ≥95% (by NMR)

Supplier: Adipogen
Description: Polarity fluorescent probe.

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7-(Diethylamino)-3-(imidazol-1-ylcarbonyl)-1-benzopyran-2-one ≥97% (by HPLC)

Supplier: Adipogen
Description: fluorescent reagent for use in circular dichroic exciton method for derivatisation of hydroxyl-groups under mild conditions. The absorption at 406 nm is futher in the red than for reagents like naphthoylimidazole. The reagent offers high sensitivity through a high molar extinction coefficient.

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(5(6)-TAMRA

Supplier: Adipogen
Description: Mixed isomers of carboxytetramethylrhodamine free acid. Tetramethylrhodamine (TMR) is one of the fluorophores most often used for preparing peptide, protein, nucleotide and nucleic acid conjugates. TMR dyes have been widely used as acceptors for FAM fluorophores in a variety of FRET studies. The dye can be coupled to primary or secondary amines via standard peptide chemistry.

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5(6)-Carboxy-2',7'-dichlorofluorescein

Supplier: Adipogen
Description: Fluorescent intracellular pH indicator in the pH 4-5 range.

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FITC (fluorescein-5-isothiocyanate, fluorescein isothiocyanate isomer I)

Supplier: Adipogen
Description: Fluorescent marker for biochemical applications. Reacts under mild conditions with primary amines. Used in modification of actin at lys-61, labelling of FAB and the modification of thiol groups.

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7-Fluorobenzo-2-oxa-13-diazole-4-sulfonic acid ammonium salt

Supplier: Adipogen
Description: Fluorescent probe for thiols widely used in pre-column labeling of biological thiols for HPLC.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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