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Supplier: Adipogen
Description: Key metabolite of the ketolytic pathway generating acetyl-CoA. Stereoselective product of D-3-hydroxybutyrate dehydreogenase. Clinically and physiologically significant stereoisomer. Energy carrier from adipocytes to peripheral tissues during fasting or exercise. Endogenous inhibitor of histone deacetylases (HDACs) 1, 3 and 4. Ligand of free fatty acid receptor 3 (FFAR3; GPR41) and hydroxycarboxylic acid receptor 2 (HCAR2; GPR109B). NLRP3 inflammasome inhibitor. Prevents K+-efflux and reduces ASC oligomerization and speck formation.

Catalog Number: (102516-338)
Supplier: Adipogen
Description: NLRP3/NALP3 inflammasome activator. Specially crystallized and tested for biological activity.
Stimulates the caspase-1 activating NLRP3/NALP3 inflammasome, resulting in the production of active IL-1beta and IL-18.

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Supplier: Adipogen
Description: Building block for synthesis.

Supplier: Adipogen
Description: Widely used fluorophore well-known for preparing fluorogenic 7-Amido-4-methylcoumarin (AMC) substrates for cystine aminopeptidase and other hydrolases. Used as reference compound in enzyme assays.

Catalog Number: (102991-284)
Supplier: Adipogen
Description: CD14/TLR4 antagonist. Inhibitor of sterile inflammation. Synthetic TLR4/CD14 ligand with TLR4 modulating activities in vitro, and conferring protection against TLR4/CD14-mediated tissue damage and inflammation in vivo. Useful to explore CD14- dependent and TLR4-independent pathways and TLR4 activation by endogenous ligands (e.g. hyaluronic acid oligosaccharides, oxLDL, HMGB1) in sterile inflammation. Shown to inhibit neuropathic pain, secondary necrosis of acute drug-induced liver failure and vascular inflammation, and abdominal aortic aneurysm by blocking non-hematopoietic TLR4 signaling. Useful tool, where inhibition of sterile (auto-) inflammation is desired, without compromising TLR4’s key role in the defense of pathogens.


Catalog Number: (102990-016)
Supplier: Adipogen
Description: Phenoxy herbicide. Compound can be used as analytical reference material. Grass-selective herbicide that acts by inhibiting fatty acid synthesis de novo in sensitive species. Mode of action is through acetyl-CoA carboxylase (ACC) inhibition.


Supplier: Adipogen
Description: Fluorescent reagents (probe, stain, label) with reactive functional group for chromatography or spectroscopy. Derivatization agent. Used for membrane research, luminescent detection, molecular biology, protein modifications, protein structural analysis and proteomics. Carbohydrate labels for chromatography.

Catalog Number: (102980-440)
Supplier: Adipogen
Description: Kynurenine aminotransferases (KATs) are pyridoxal-5’-phosphate-dependent enzymes that catalyze the conversion of L-kynurenine into kynurenic acid, a neuroactive metabolite whose unbalancing is associated with a number of brain disorders


Supplier: Adipogen
Description: PIK-294 is a PI3 Kinase inhibitor that is 20- to 60-fold more potent than the parent compound, PIK-293. It is one of the most potent p110delta-selective inhibitors that has been reported, with an IC(50) of 10nM.

Supplier: Adipogen
Description: For application to living cells, the diacetyl derivative of ZnAF-1F, ZnAF-1F DA, was synthesized. ZnAF-1F DA can permeate through the cell membrane, and is hydrolyzed by esterase in the cytosol to yield ZnAF-1F, which is retained in the cells. ZnAF-1F DA has been used to measure the changes of intracellular Zn2+ in cultured cells and hippocampal slices. Spectral data: lambdaex 492nm; lambdaem 514nm in PBS.

Supplier: Adipogen
Description: Control for H2S2 and hydrogen polysulfides probes.

Supplier: Adipogen
Description: Potent histone acetyltransferase (HAT) inhibitor. Antibacterial. SUMOylation inhibitor. Lipoxygenase inhibitor. NF-kappaB inhibitor. Anti-tumor compound. Anti-inflammatory. Apoptosis inducer. Antiproliferative.

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Supplier: Adipogen
Description: Retinol binding protein 4 (RBP4; RBP) is a 21kDa secreted protein, a member of the lipocalin family and is known as the primary transporter of retinol (vitamin A) to tissues. A recent report revealed RBP4 as an adipokine linking glucose transporter 4 (GLUT4) suppression in adipose tissue to insulin. Elevated human and mouse serum RBP4 levels are associated with insulin resistance and its severity, obesity, and certain components of metabolic syndrome. Furthermore, human serum RBP4 levels are closely related to renal function.

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Supplier: Adipogen
Description: Flusulfamide is primarily a soil-applied fungicide. It controls selected myxomycete fungi by preventing germination of both resting spores and secondary zoospores. The mode of action is not clear, however it activity might be attributed to cleavage of key structures within the spore cell walls. Compound can be used as analytical reference material.

Supplier: Adipogen
Description: IL-36Ra/IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are target of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.

Supplier: Adipogen
Description: TG100115 inhibits PI3Kgamma and delta, with IC(50) values of 83 and 235nM, respectively.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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