IAXO-103 (CD14/TLR4 Antagonist) (synthetic) ≥98% (by TLC)
Supplier: ADIPOGEN CORP MS
Synonyms:
N-(3,4-bis-Tetradecyloxy-benzyl)-N-cyclopentyl-N,N-dimethylammonium iodide
CD14/TLR4 antagonist. Inhibitor of sterile inflammation. Synthetic TLR4/CD14 ligand with TLR4 modulating activities in vitro, and conferring protection against TLR4/CD14-mediated tissue damage and inflammation in vivo. Useful to explore CD14- dependent and TLR4-independent pathways and TLR4 activation by endogenous ligands (e.g. hyaluronic acid oligosaccharides, oxLDL, HMGB1) in sterile inflammation. Shown to inhibit neuropathic pain, secondary necrosis of acute drug-induced liver failure and vascular inflammation, and abdominal aortic aneurysm by blocking non-hematopoietic TLR4 signaling. Useful tool, where inhibition of sterile (auto-) inflammation is desired, without compromising TLR4’s key role in the defense of pathogens.
Formula:
C₄₂H₇₈INO₂ Storage Temperature: Refrigerator |
CAS Number:
1202208-36-3 |
Specification Test Results
Source/Host | Synthetic. |
Purity | >98% (TLC) |
Appearance/Color | White solid. |
Solubility | Soluble in Methanol, DMSO and Ethanol 1:1 (vol:vol): >10mM. |
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