IAXO-103 (CD14/TLR4 Antagonist) (synthetic) ≥98% (by TLC)

Supplier: ADIPOGEN CORP MS

Synonyms: N-(3,4-bis-Tetradecyloxy-benzyl)-N-cyclopentyl-N,N-dimethylammonium iodide

IAX-600-003-M001
102991-284EA 355.85 USD
102991-284
IAXO-103 (CD14/TLR4 Antagonist) (synthetic) ≥98% (by TLC)
IAXO-103 (CD14/TLR4 Antagonist)

CD14/TLR4 antagonist. Inhibitor of sterile inflammation. Synthetic TLR4/CD14 ligand with TLR4 modulating activities in vitro, and conferring protection against TLR4/CD14-mediated tissue damage and inflammation in vivo. Useful to explore CD14- dependent and TLR4-independent pathways and TLR4 activation by endogenous ligands (e.g. hyaluronic acid oligosaccharides, oxLDL, HMGB1) in sterile inflammation. Shown to inhibit neuropathic pain, secondary necrosis of acute drug-induced liver failure and vascular inflammation, and abdominal aortic aneurysm by blocking non-hematopoietic TLR4 signaling. Useful tool, where inhibition of sterile (auto-) inflammation is desired, without compromising TLR4’s key role in the defense of pathogens.

Formula: C₄₂H₇₈INO₂
Storage Temperature: Refrigerator
CAS Number: 1202208-36-3

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Specification Test Results

Source/Host Synthetic.
Purity >98% (TLC)
Appearance/Color White solid.
Solubility Soluble in Methanol, DMSO and Ethanol 1:1 (vol:vol): >10mM.


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