You Searched For: 0000027161

Supplier: Adipogen

Description: Potent inhibitor of tumor promoting phorbol ester TPA/PMA (AG-CN2-0010) effects in vivo. Antifungal. Moderate immunosuppressant. Calcineurin inhibitor with lower activity than Cyclosporin A (AG-CN2-0079). Moderate inhibitor of formyl peptide-induced superoxide formation.

Supplier: Adipogen

Description: Cell permeable superoxide dismutase (SOD) mimetic. Peroxynitrite scavenger. Displays a protective effect against H2O2 mediated injury. Neuroprotective. Oxidative stress inhibitor. Apoptosis inhibitor. Reduces inflammation.

Supplier: Adipogen

Description: Sensitive probe for membrane potential (Ex/Em: 555/578nm in methanol). Selective staining of immature hemopoietic cells in flow cytometry.

Supplier: Adipogen

Description: Beta-Aminoisobutyric acid is a non-protein amino acid originating from the catabolism of thymine and valine. beta-Aminoisobutyric acid occurs in two isomeric forms and both enantiomers of beta-Aminoisobutyric acid can be detected in human urine and plasma. In plasma, the S-enantiomer is the predominant type due to active renal reabsorption. In contrast, urine almost exclusively contains the R-enantiomer of beta-Aminoisobutyric acid, which is eliminated both by filtration and tubular secretion. The S-enantiomer of beta-Aminoisobutyric acid is predominantly derived from the catabolism of valine, the R-enantiomer is the product of the catabolism of the pyrimidine bases uracil and thymine by the enzyme dihydropyrimidine dehydrogenase (DPD), in what constitutes the first step of the pyrimidine degradation pathway. Transient high levels of beta-Aminoisobutyric acid have been observed under a variety of pathological conditions such as lead poisoning, starvation, in total body irradiation and in a number of malignancies. Recently R-/S-enantiomer mixtures have been shown to be browning inducer of white adipose tissue.

Supplier: Adipogen

Description: TAK-715 is a potent specific inhibitor of the p38alpha MAP kinase with an IC(50) of 7.1nM. It is approximately 30-fold more selective for p38alpha over p38beta. It shows no inhibition of p38gamma/delta.

Supplier: Adipogen

Description: Hordenine is a phenethylamine type alkaloid found naturally in various plants such as barley and cacti. Hordenine may be used as an analytical reference material and in research on the activities of phenethylamine type alkaloids. Quorum-sensing inhibitor (QSI).

Supplier: Adipogen

Description: Isoprothiolane is a dithiolane pesticide. Isoprothiolane is commonly used in agriculture as a fungicide and insecticide to control planthoppers and blast disease in rice plants. Shown to regulate mammary epithelial cell growth in vitro by modulation production of cytokines and improving hepatic lipid metabolism in cows. Compound can be used as analytical reference material.

Supplier: Adipogen

Description: Cell permeable GLI antagonist. Inhibits Gli1 and Gli2-induced transcription. Sonic hedgehog (Shh) signaling pathway inhibitor, downstream of SMO and SUFU. Displays antiproliferative and antitumor activity in vitro and in vivo. Apoptosis inducer.

Supplier: Adipogen

Description: Brivanib inhibits VEGFR-2 with an IC(50) of 25nM and a Ki of 26nM, VEGFR-1 with an IC(50) of 380nM and VEGFR-3 with an IC(50) of 10nM. It also shows selectivity for FGFR-1 with an IC(50) of 148nM, FGFR-2 with an IC(50) of 25nM and FGFR-3 with an IC(50) of 68nM.

Supplier: Adipogen

Description: AS-252424 is a potent and selective PI3K inhibitor. It inhibits human recombinant PI3K alpha, beta, gamma and delta with IC(50) values of 30, 940, 20,000, and 20,000nM respectively.

Catalog Number: (102513-732)

Supplier: Adipogen

Description: Reductiomycin is an anti-bacterial antibiotic.

Catalog Number: (102978-636)

Supplier: Adipogen

Description: Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7.

Catalog Number: (102978-654)

Supplier: Adipogen

Description: The anti-IgG (rat), pAb (HRP) is cross-adsorbed against pooled mouse sera and pooled mouse plasmacytoma/hybridoma proteins and affinity-purified on pooled rat IgG covalently linked to agarose.

Catalog Number: (102981-792)

Supplier: Adipogen

Description: CD273 (B7-DC; PD-L2) is a type I surface molecule with homology to CD80, CD86, CD274. It is expressed primarily by dendritic cells and provides a stimulatory signal to CD279 (PD-1; Programmed Cell Death 1) which has an important immunoregulatory role by downregulating the T cell response. CD273 binds to CD279 (PD-1) with a 2-6 fold higher affinity than CD274 and is an important component of immune regulation.

Catalog Number: (102512-214)

Supplier: Adipogen

Description: Human CD30 is a member of the TNF receptor family and is expressed on mitogen activated B and T cells.

Catalog Number: (102512-260)

Supplier: Adipogen

Description: Human CD34 is an unusual glycosylated membrane protein exclusively expressed on immature hematopoietic cells and on endothelial cells. CD34 may have a role in cell adhesion. CD34 has extensive utility for bone marrow transplantation.