You Searched For: ADIPOGEN CORP MS

Catalog Number: (102512-776)

Supplier: Adipogen

Description: Immunoglobulin expressed by the mouse plasmacytoma MOPC 31C is an IgG1kappa isotype of unknown specificity. It is used as a negative control when working with human cells.

Catalog Number: (102514-462)

Supplier: Adipogen

Description: IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T-cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T-cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.

Catalog Number: (102514-464)

Supplier: Adipogen

Description: Nicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an 52kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.

Catalog Number: (102514-528)

Supplier: Adipogen

Description: Microfibril-associated protein 4 (MFAP4) was initially identified as a gene commonly deleted in the contiguous Smith-Magenis syndrome (SMS) gene. MFAP4 was identified as growth factor to support expansion of hematopoietic stem cells in culture. It is involved in calcium-dependent cell adhesion and intercellular interactions.

Catalog Number: (102514-474)

Supplier: Adipogen

Description: ANGPTL6 regulates angiogenesis and also directly regulates lipid, glucose, and energy metabolism. The serum levels of ANGPTL6 are significantly increased in obese humans, patients with type 2 diabetes mellitus (T2DM), and in metabolic syndrome.

Catalog Number: (102514-512)

Supplier: Adipogen

Description: Retinol binding protein 4 (RBP4; RBP) is a 21kDa secreted protein, a member of the lipocalin family and is known as the primary transporter of retinol (vitamin A) to tissues. A recent report revealed RBP4 as an adipokine linking glucose transporter 4 (GLUT4) suppression in adipose tissue to insulin. Elevated human and mouse serum RBP4 levels are associated with insulin resistance and its severity, obesity, and certain components of metabolic syndrome. Furthermore, human serum RBP4 levels are closely related to renal function.

Catalog Number: (102513-044)

Supplier: Adipogen

Description: Human CD49f molecules are integrin alpha 6 chains that are expressed as heterodimers with CD29 (beta 1 integrin) or CD104 (beta 4 integrin) and function as adhesion receptors. CD49f is expressed on platelets, monocytes, T lymphocytes and thymoctyes.

Catalog Number: (102513-040)

Supplier: Adipogen

Description: Human CD134 (OX40; ACT35) is an activation-associated antigen which is predominantly expressed on activated CD4 positive cells. CD134 antigen is a member of the TNF receptor family of molecules and may be involved with regulating T cell-dependent B cell proliferation and differentiation.

Catalog Number: (102513-004)

Supplier: Adipogen

Description: CD127 (IL-7Ra) is the specific receptor component for the cytokine interleukin-7 (IL-7). It is found on a wide variety of hematopoietic cell types including B cell precursors and the majority of T cells. Its expression levels are decreased on T cells following activation. CD127 can dimerize with CD132 (IL-2Rgamma) to form a high affinity IL-7 receptor. CD127 engagement is necessary for T cell development in humans.

Catalog Number: (102512-970)

Supplier: Adipogen

Description: Human CD105 (endoglin) is a homodimeric membrane glycoprotein virtually restricted to endothelial cells and present on some leukemia cells and minor subsets of bone marrow cells. CD105 binds to TGF-beta1 and beta3 with high affinity.

Catalog Number: (102513-018)

Supplier: Adipogen

Description: Human CD44 molecules appear to serve as lymphocyte adhesion molecules with numerous functions in extracellular matrix binding, cell migration, hemopoisis and lymphocyte homing.

Catalog Number: (102513-006)

Supplier: Adipogen

Description: CD127 (IL-7Ra) is the specific receptor component for the cytokine interleukin-7 (IL-7). It is found on a wide variety of hematopoietic cell types including B cell precursors and the majority of T cells. Its expression levels are decreased on T cells following activation. CD127 can dimerize with CD132 (IL-2Rgamma) to form a high affinity IL-7 receptor. CD127 engagement is necessary for T cell development in humans.

Catalog Number: (102513-036)

Supplier: Adipogen

Description: Human CD134 (OX40; ACT35) is an activation-associated antigen which is predominantly expressed on activated CD4 positive cells. CD134 antigen is a member of the TNF receptor family of molecules and may be involved with regulating T cell-dependent B cell proliferation and differentiation.

Catalog Number: (102513-050)

Supplier: Adipogen

Description: Human CD49f molecules are integrin alpha 6 chains that are expressed as heterodimers with CD29 (beta 1 integrin) or CD104 (beta 4 integrin) and function as adhesion receptors. CD49f is expressed on platelets, monocytes, T lymphocytes and thymoctyes.

Catalog Number: (102513-046)

Supplier: Adipogen

Description: Human CD49f molecules are integrin alpha 6 chains that are expressed as heterodimers with CD29 (beta 1 integrin) or CD104 (beta 4 integrin) and function as adhesion receptors. CD49f is expressed on platelets, monocytes, T lymphocytes and thymoctyes.

Catalog Number: (102514-720)

Supplier: Adipogen

Description: Negative control in assays where proteins fused to human Fc (IgG1) or human IgG1 monoclonal antibodies are used.