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5-Hydroxymethylcytosine ≥98% (by NMR)

Catalog Number: (102988-906)
Supplier: Adipogen
Description: Modified base of mammalian DNA. Involved in regulation of stem cell processes, cellular development, neurodegeneration and carcinogenesis. Important epigenetic marker. Related to bacimethrin .
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(S)-Roscovitine ≥99% (by NMR)

Supplier: Adipogen
Description: (S)-enantiomer of (R)-roscovitine . Potent selective cyclin-dependent kinase 1 (CDK1) inhibitor. Potential neuroprotectant for stroke. Crosses the blood brain barrier. Inhibits CDK5, consequently blocking hypoxia-induced apoptosis in neurons. Potential anti-inflammatory compound. Potential antidiabetic compound.

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Anti-RANKL Rabbit Polyclonal Antibody

Catalog Number: (102514-426)
Supplier: Adipogen
Description: RANKL is an osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. Important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. Plays an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
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Anti-Adiponectin Rabbit Polyclonal Antibody

Catalog Number: (102514-382)
Supplier: Adipogen
Description: ACRP30 was identified as a novel adipocyte-specific synthesized and secreted protein with structural resemblance to complement factor C1q. Like adipsin, ACRP30 secretion is induced ~10-fold during adipocyte differentiation. Plasma levels are reduced in obese humans, and low levels are associated with insulin-resistance. Treatment of db/db mice with TZD increased ACRP30 levels.
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Anti-beta-Pix Rabbit Polyclonal Antibody

Catalog Number: (102514-386)
Supplier: Adipogen
Description: beta-PIX acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. It interacts with PAK kinases through the SH3 domain. It may function as a positive regulator of apoptosis and is involved in cell migration. It is expressed with high levels in the central nervous system.
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Anti-BAFF Rat Monoclonal Antibody [clone: 1-35-1]

Catalog Number: (102514-342)
Supplier: Adipogen
Description: BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren's syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).
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Anti-AIM2 Mouse Monoclonal Antibody [clone: 3B10]

Catalog Number: (102514-350)
Supplier: Adipogen
Description: AIM2 is a strong candidate as a tumor suppressor as it is a member of the HIN-200 (hemopoietic interferon-inducible, nuclear proteins containing a 200 amino acid repeat) family of proteins that have been shown to regulate cell growth and survival. The HIN-200 family of proteins consists of four members in human, IFI 16, MNDA, AIM2 and IFIXl. Recently it has been reported that AIM2 is a receptor for cytosolic dsDNA, which forms a novel inflammasome complex with ASC to activate caspase-1-mediated processing of IL-1beta.
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Anti-CD166 Monoclonal Antibody (Biotin) [clone: 3A6]

Catalog Number: (102513-162)
Supplier: Adipogen
Description: Human CD166 is a type 1 glycoprotein expressed on activated T cells, B cells and monocytes and appears to be the ligand for CD6. Human CD166 may be important for activation of T cells.

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Anti-CD252 Monoclonal Antibody [clone: ANC10G1]

Catalog Number: (102513-198)
Supplier: Adipogen
Description: Human CD252 (CD134L; OX40 ligand) is a type II membrane protein with homology to TNF which is expressed on activated B cells and activated endothelial cells. CD252 binds to CD134 (OX40) present on activated T cells, providing a costimulatory signal. Blockade of this interaction in mouse abrogated immunological effects in several models of inflammation and rejection.

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Anti-CD6 Monoclonal Antibody [clone: 3F7B6]

Catalog Number: (102511-932)
Supplier: Adipogen
Description: Human CD6 is expressed on peripheral blood T cells, most thymocytes and a subset of B cells. CD6 is similar to CD5 and contains three cysteine-rich domains with structural homology to the macrophage scavenger receptor. CD6 is involved in T cell activation and its ligand was recently identified.

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Anti-CD5 Monoclonal Antibody [clone: UCHT2]

Catalog Number: (102511-920)
Supplier: Adipogen
Description: Human CD5 is believed to be an alternative signaling molecule found on all mature T cells, on most thymocytes and on a subpopulation of mature B cells expressing autoantibodies. The ligand for CD5 is CD72.

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Anti-CD4 Monoclonal Antibody (R-PE) [clone: M-T441]

Catalog Number: (102511-916)
Supplier: Adipogen
Description: Human CD4 is a cell surface glycoprotein of 55kDa expressed on most thymocytes, on about two thirds of peripheral T cells and on some monocyte macrophage lineage cells. CD4 interacts with MHC Class II molecules in an accessory role during foreign antigen recognition by T cells. The extracellular portion of CD4 is an array of four Ig-like domains. The N-terminal region of CD4 is a receptor for the HIV-1 viral protein gp120.

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Anti-CD1c Monoclonal Antibody (FITC) [clone: M241]

Catalog Number: (102511-888)
Supplier: Adipogen
Description: The human CD1 genetic locus consists of five closely related genes. Three of the gene products (CD1a, CD1b and CD1c) have been officially clustered using antibodies and are expressed on cortical thymocytes, a subset of B cells, and on most professional antigen presenting cells. CD1 molecules have a specialized lipid antigen-presenting function and it is unlikely that they present conventional peptide antigens. CD1 may also be involved in costimulation.

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Anti-CD1a Monoclonal Antibody [clone: CB-T6]

Catalog Number: (102511-872)
Supplier: Adipogen
Description: The human CD1 genetic locus consists of five closely related genes. Three of the gene products (CD1a, CD1b and CD1c) have been officially clustered using antibodies and are expressed on cortical thymocytes, a subset of B cells, and on most professional antigen presenting cells. CD1a+/CD11c+ dendritic cells are direct precursors of Langerhans cells in peripheral blood. CD1 molecules have a specialized lipid antigen-presenting function.

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Image Unavailable-102512-806

Mouse IgG2a Isotype Control [clone: RPC 5] (RPC 5) (APC)

Catalog Number: (102512-806)
Supplier: Adipogen
Description: Immunoglobulin expressed by the mouse plasmacytoma hybridoma RPC 5 is an IgG2a isotype of unknown specificity. It is used as a negative control when working with human cells.

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Mouse IgG2a Isotype Control [clone: RPC 5] (RPC 5) (Biotin)

Catalog Number: (102512-800)
Supplier: Adipogen
Description: Immunoglobulin expressed by the mouse plasmacytoma hybridoma RPC 5 is an IgG2a isotype of unknown specificity. It is used as a negative control when working with human cells.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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