Anti-IL-38 Monoclonal Antibody [clone: Nhat-1]

Supplier: Adipogen
AG-20B-0070-C100
102971-630EA 553.85 USD
102971-630
Anti-IL-38 Monoclonal Antibody [clone: Nhat-1]
Antibodies
IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 as a IL-1 family receptor antagonist. Il-38 inhibits IL-36 signaling by binding to IL-1R6. IL-38 (aa 20-152) is released from apoptotic cells to limit inflammatory macrophage and downstream Th17 activation by blocking IL1RAPL1 (Interleukin-1 receptor accessory protein-like 1, TIGIRR-2) signaling. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.

Type: Primary
Antigen: IL-38
Clonality: Monoclonal
Clone: Nhat-1
Conjugation: Unconjugated
Epitope:
Host:
Isotype: Mouse IgG2bkappa.
Reactivity: Human, Mouse
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