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Carboplatin

Supplier: Adipogen
Description: Potent platinum-based antineoplastic agent. Analog of cisplatin (Prod. No. AG-CR1-3590) with reduced nephrotoxicity and higher stability. Antitumor agent. Forms inter- and intrastrand DNA adducts/crosslinks, consequently blocking DNA replication and transcription and inducing cell death. Interferes with cell division by mitosis. The damaged DNA elicits DNA repair mechanisms, which in turn activate apoptosis when repair is impossible. Apoptosis inducer. Enhances radiation-induced single-strand DNA breakage.

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OCH 95

Supplier: Adipogen
Description: Truncated analog of alpha-GalCer. iNKT cell glycolipid agonist. Immunosuppressive. Th2 polarizing. Stimulation of NKT with OCH results in release of primarily Th2 cytokine compared to stimulation with alpha-GalCer, which results in release of a mixture of Th1 and Th2 cytokines. Induces stronger interleukin-4 (IL-4) secretion and weaker interferon-gamma (IFN-gamma) secretion than alpha-GalCer both in vitro and in vivo. Inducer of interleukin-10 (IL-10) and suppressor of diabetes. Shown to prevent experimental autoimmune encephalomyelitis (EAE) in mice, an animal model of multiple sclerosis. Has beneficial effects on type I diabetes in NOD mice. Suppressor of collagen-induced arthritis. Might be useful for immunotherapy of transplant rejection.

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IC87114 95

Supplier: Adipogen
Description: IC87114 is a potent, ATP-competitive, and selective inhibitor of PI3Kdelta. IC(50) values (130-500nM) for IC87114 are sub-micromolar over a wide range of ATP concentrations from 10µM to 200µM. IC87114 can selectively inhibit cellular migration but not adhesion as well as cellular polarization. More recent work has shown the PIK3delta inhibition also plays a role in autoimmune disease suppression.

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Masatinib 95

Supplier: Adipogen
Description: Masitinib is a potent, orally available protein tyrosine kinase inhibitor targeting c-Kit, PDGFR and FGFR3. It demonstrates activity for Kit and PDGFRalpha/beta with IC(50) values of 200nM, 540nM and 800nM respectively. It shows weak inhibition of ABL and c-Fms.

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Anti-DLL1 Mouse Monoclonal Antibody [clone: D1L165-6]

Supplier: Adipogen
Description: The Notch ligand delta-like protein 1 (DLL1) is essential for postnatal arteriogenesis and contributes to tumor progression. DLL1 is involved in differentiation and self-renewal of adipocyte stem cells. Blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.

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Anti-CD75 Monoclonal Antibody [clone: LN1]

Catalog Number: (102512-592)
Supplier: Adipogen
Description: Human CD75 is an alpha 2, 6-sialylated carbohydrate molecule found mainly on mature B cells and germinal center B cells and also in T cell subsets and erythrocitic cells. CD75 appears to be a ligand for CD22.

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Mouse Recombinant FTO (from E. coli)

Catalog Number: (102515-140)
Supplier: Adipogen
Description: FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes’ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.

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IPTG (isopropyl-β-D-thiogalactopyranoside) dioxane_free

Supplier: Adipogen
Description: Molecular biology reagent. beta-Galactosidase activity inducer in several bacteria, by binding and inhibiting the lac repressor. Used in gene cloning together with X-Gal (Prod. No. AG-CC1-0003), in a technique called blue/white screening. Distinguishes between recombinant and non-recombinant plasmids carrying the beta-galactosidase gene. Plant origin, contains no animal-derived contaminants. Stimulates beta-galactosidase in cellular systems in which dioxane would disrupt normal cell function.

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Concanamycin C Streptomyces species 98 HPLC_ASSAY_METHOD, high_purity

Supplier: Adipogen
Description: Concanamycin C is an anti-viral, immunosuppressive antibiotic.

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Concanamycin A Streptomyces species 98 HPLC_ASSAY_METHOD, high_purity

Supplier: Adipogen
Description: Concanamycin A is an antibiotic isolated from <i>Streptomyces sp</i>. which is a more potent and specific H⁺ -ATPase inhibitor than Bafilomycin A₁. It inhibits acidification of organelles, such as lysosomes and the Golgi apparatu,s and blocks cell surface expression of viral glycoproteins without affecting their synthesis.

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Anti-CD5 Monoclonal Antibody (R-PE) [clone: UCHT2]

Catalog Number: (102511-928)
Supplier: Adipogen
Description: Human CD5 is believed to be an alternative signaling molecule found on all mature T cells, on most thymocytes and on a subpopulation of mature B cells expressing autoantibodies. The ligand for CD5 is CD72.

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Anti-CD6 Monoclonal Antibody (R-PE) [clone: 3F7B6]

Catalog Number: (102511-938)
Supplier: Adipogen
Description: Human CD6 is expressed on peripheral blood T cells, most thymocytes and a subset of B cells. CD6 is similar to CD5 and contains three cysteine-rich domains with structural homology to the macrophage scavenger receptor. CD6 is involved in T cell activation and its ligand was recently identified.

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Anti-CD6 Monoclonal Antibody (Biotin) [clone: 3F7B6]

Catalog Number: (102511-934)
Supplier: Adipogen
Description: Human CD6 is expressed on peripheral blood T cells, most thymocytes and a subset of B cells. CD6 is similar to CD5 and contains three cysteine-rich domains with structural homology to the macrophage scavenger receptor. CD6 is involved in T cell activation and its ligand was recently identified.

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Anti-CD4 Monoclonal Antibody (R-PE) [clone: QS4120]

Catalog Number: (102511-900)
Supplier: Adipogen
Description: Human CD4 is a cell surface glycoprotein of 55kDa expressed on most thymocytes, on about two thirds of peripheral T cells and on some monocyte macrophage lineage cells. CD4 interacts with MHC Class II molecules in an accessory role during foreign antigen recognition by T cells. The extracellular portion of CD4 is an array of four Ig-like domains. The N-terminal region of CD4 is a receptor for the HIV-1 viral protein gp120.

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Anti-CD4 Monoclonal Antibody [clone: QS4120]

Catalog Number: (102511-892)
Supplier: Adipogen
Description: Human CD4 is a cell surface glycoprotein of 55kDa expressed on most thymocytes, on about two thirds of peripheral T cells and on some monocyte macrophage lineage cells. CD4 interacts with MHC Class II molecules in an accessory role during foreign antigen recognition by T cells. The extracellular portion of CD4 is an array of four Ig-like domains. The N-terminal region of CD4 is a receptor for the HIV-1 viral protein gp120.

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Anti-CD3 Monoclonal Antibody (FITC) [clone: UCHT1]

Catalog Number: (102511-862)
Supplier: Adipogen
Description: The human CD3/T cell receptor (TcR) complex is made up of the CD3 proteins (gamma, delta, 2 epsilon) and teh zeta-chain in association with either alpha/beta or gamma/delta proteins of the TcR. The TcR recognizes antigens in association with MHC molecules after which protein chains of the CD3 complex mediate activation signals triggered by TcR antigen binding. CD3 is expressed on greater than 95% of circulating human peripheral T cells.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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  • State issued document with your organization's Federal Tax ID Number
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* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. VWR will not lift restrictions for residential shipping addresses.

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This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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