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Catalog Number: (102512-480)
Supplier: Adipogen
Description: Human CD57 originally called HNK-1, is a glycoprotein found on 15-20 % of PBL’s (peripheral blood lymphocytes) including 60 % of NK cells and a subset of T cells. The immune regulation role of CD57 positive PBL’s expressing high levels of CD8 is being investigated.

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Catalog Number: (102512-476)
Supplier: Adipogen
Description: Human CD57 originally called HNK-1, is a glycoprotein found on 15-20 % of PBL’s (peripheral blood lymphocytes) including 60 % of NK cells and a subset of T cells. The immune regulation role of CD57 positive PBL’s expressing high levels of CD8 is being investigated.

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Catalog Number: (102512-550)
Supplier: Adipogen
Description: Human CD69 is expressed by platelets and mature thymocytes and appears rapidly after activation on T cells, B cells and NK cells. This pattern of cellular CD69 expression has suggested a lymphocyte activation role. Functional studies with antibodies to CD69 also support an activation role for CD69.

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Catalog Number: (102512-474)
Supplier: Adipogen
Description: Human CD56 is an adhesion molecule from the Ig superfamily which is restricted to NK cells in the immune system. It is believed that NK cells form a first line of defense against tumor cells and cells infected with bacteria and viruses.

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Catalog Number: (102512-722)
Supplier: Adipogen
Description: The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

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Catalog Number: (102512-734)
Supplier: Adipogen
Description: Glucocorticoid induced TNF receptor family related gene (GITR; AITR) is a type 1 228 amino acid transmembrane protein that has been designated TNFRSF18. GITR is expressed mainly by CD4+ CD25+ T lymphocytes. Its engagement by antibodies or its ligand (GITRL) induces a costimulatory signal which can break T cell suppression. GITR has been implicated as a regulatory mechanism in anti-parasitic immune resposes, and is involved with macrophages activation in atherosclerotic plaque formation.

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Catalog Number: (102512-712)
Supplier: Adipogen
Description: BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren’s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).

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Catalog Number: (102512-706)
Supplier: Adipogen
Description: The inducible costimulator CD278 (ICOS) is similar to human CD28 (24% homology) and plays an analogous role in the T cell activation process. Secondary signaling through CD28 or CD278 results in discrete cytokine secretion profiles by the activated T cells. CD275 (ICOSL; GL50; B7-H2) has been shown to be the ligand for CD278 (ICOS).

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Catalog Number: (102511-886)
Supplier: Adipogen
Description: The human CD1 genetic locus consists of five closely related genes. Three of the gene products (CD1a, CD1b and CD1c) have been officially clustered using antibodies and are expressed on cortical thymocytes, a subset of B cells, and on most professional antigen presenting cells. CD1 molecules have a specialized lipid antigen-presenting function and it is unlikely that they present conventional peptide antigens. CD1 may also be involved in costimulation.

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Catalog Number: (102511-870)
Supplier: Adipogen
Description: The human CD3/T cell receptor (TcR) complex is made up of the CD3 proteins (gamma, delta, 2 epsilon) and teh zeta-chain in association with either alpha/beta or gamma/delta proteins of the TcR. The TcR recognizes antigens in association with MHC molecules after which protein chains of the CD3 complex mediate activation signals triggered by TcR antigen binding. CD3 is expressed on greater than 95% of circulating human peripheral T cells.

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Catalog Number: (102511-940)
Supplier: Adipogen
Description: Human CD7 is one of the earliest T lineage markers and is found on most thymocytes and peripheral blood T cells. The function of CD7 is not yet fully known, although cross-linking of CD7 with antibodies induces a T cell transmembrane calcium flux and CD7 expression is induced by ionomycin.

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Catalog Number: (102512-778)
Supplier: Adipogen
Description: Immunoglobulin expressed by the mouse plasmacytoma MOPC 31C is an IgG1kappa isotype of unknown specificity. It is used as a negative control when working with human cells.

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Catalog Number: (102512-826)
Supplier: Adipogen
Description: Immunoglobulin expressed by the mouse plasmacytoma hybridoma SIPC 3385 is an IgG3 isotype of unknown specificity. It is used as a negative control when working with human cells.

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Catalog Number: (102512-812)
Supplier: Adipogen
Description: Immunoglobulin expressed by the mouse plasmacytoma hybridoma BPC 4 is an IgG2bkappa isotype of unknown specificity. It is used as a negative control when working with human cells.

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Catalog Number: (102512-846)
Supplier: Adipogen
Description: CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.

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Catalog Number: (102512-838)
Supplier: Adipogen
Description: Human IgG1kappa from human myeloma plasma is used as a negative control for work involving human IgG1 isotype antibodies or recombinant proteins.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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