You Searched For: ADIPOGEN CORP MS

Supplier: Adipogen

Description: Antibiotic

Supplier: Adipogen

Description: Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GM1 is a major sialoglycolipid of neuronal membranes that modulates calcium homeostasis and which is important for neuronal plasticity and repair mechanisms. It binds to cholera toxin B subunit, resulting in stimulation of adenylyl cyclase in a wide variety of cell types. After cholera toxin binds to membrane associated Monosialoganglioside GM1, the A subunit of cholera toxin is translocated to the cell interior, where it catalyzes the ADP ribosylation of the membrane associated Gs subunit of adenylyl cyclase. In addition, binding of cholera toxin to monosialoganglioside GM1 causes translocation of NF-kappaB and activation of dendritic cells. E. coli heat-labile enterotoxin (LT) is structurally and functionally similar to cholera toxin and binds GM1 as well. GM1 has also been shown to improve Parkinson's disease symptoms and slow it's progression.

Supplier: Adipogen

Description: Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome. Excitation: 345nm. Emission: 445nm. This substrate is useful for inhibitor screening and kinetic analysis.

Catalog Number: (102988-486)

Supplier: Adipogen

Description: Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome. Fluorogenic substrate for calpain and papain. Peptide substrate for Ti protease from E.coli. Excitation: 360nm. Emission: 460nm. This substrate is useful for inhibitor screening and kinetic analysis.

Supplier: Adipogen

Description: Selective Ub-conjugating enzyme (E2) complex Ubc13-Uev1A inhibitor. Inhibits the formation of the Ubc13~Ub conjugate. NF-kappaB activation inhibitor. Inhibits proliferation and survival of ABC-DLBCL and GCB-DLBCL (diffuse large B cell lymphoma) cells.

Supplier: Adipogen

Description: Aza-steroid. Hedgehog signaling inhibitor. Competes with 20(S)-OHC for access to the cysteine-rich domain in Smoothened (Smo). For control compound see 22-NHC (inactive isomer) http://www.adipogen.com/ag-cr1-3524/22-nhc-inactive-isomer.html .

Catalog Number: (102988-998)

Supplier: Adipogen

Description: Isomeric to pseurotin A . Anticancer and antiparasitic compound. Apomorphine antagonist. Neuroleptic agent. Inhibitor of IgE production.

Catalog Number: (102989-086)

Supplier: Adipogen

Description: Cytochalasan mycotoxin, derivative of chaetoglobosin A . Phytotoxic and antifungal compound. Moderate cytotoxic compound.

Catalog Number: (102989-068)

Supplier: Adipogen

Description: Venturicidin A is a 20-Membered macrolide glycoside.

Supplier: Adipogen

Description: 7-Azido-4-methylcoumarin is a highly sensitive and selective fluorogenic H2S probe. The aromatic azide moiety of AzMC is selectively reduced in the presence of H2S, producing the fluorescent 7-amino-4-methylcoumarin (AMC) with a concomitant increase in fluorescence with lambdaex = 365 nm and lambdaem = 450 nm. It is a photoaffinity labeling probe for the substrate binding site of human sulfotransferase 1A1 (SULT1A1). 7-Azido-4-methylcoumarin is a tool for monitoring the activity of pyridoxal-5'-phosphate (PLP)-dependent enzymes (e.g. cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CGL) and tryptophan synthase (TS)) and to identify novel cystathionine beta-synthase (CBS) inhibitors and activators.

Supplier: Adipogen

Description: Cytotoxic. Melanogenesis inhibitor without cytotoxicity.

Supplier: Adipogen

Description: Multipotent flavonoid antioxidant. Potent free radical scavenger. Neuroprotective. Anticancer compound with chemosensitizing activity. Cell cycle arrest, apoptosis and autophagy inducer. Proteasome inhibitor. Pleiotropic kinase inhibitor, including tyrosine protein kinase (Trk), mitochondrial ATPase, cAMP- and cGMP-phosphodiesterases, PI3-kinase activity, phospholipase A2 and protein kinase C (PKC). DNA topoisomerases inhibitor. SIRT1 activator. Heat shock proteins inhibitor. Reversible fatty acid synthase inhibitor. Antithrombotic, antihistaminic and anti-inflammatory agent. Monoamine oxidase inhibitor. Vasodilatory compound. anti-diabetic compound.

Supplier: Adipogen

Description: Toxic sesquiterpenoid. Exhibits expectorant and antitussive effect. Reported to increase blood pressure. Antifungal compound.

Supplier: Adipogen

Description: Potent platinum-based antineoplastic agent with wide spectrum anticancer activity. Anticancer compound. Forms inter- and intrastrand DNA adducts/crosslinks, consequently blocking DNA replication and transcription and inducing cell death. Shows antitumor activity in cisplatin resistant cell lines. Shows better biochemical, pharmacological and cytotoxic properties than cisplatin (Prod. No. AG-CR1-3590) and carboplatin (Prod. No. AG-CR1-3591). Apoptosis inducer. Targets other proteins and enzymes. Anticancer activity and antitumor specificity depends on selective uptake through human organic cation transporters 1 (OCT1) and OCT2. Neurotoxic profile depends on organic cation transporter 2 (OCT2) uptake.

Supplier: Adipogen

Description: Antidiabetic compound. Binds to and activates the ATP-sensitive potassium channels (KATP) inhibitory regulatory subunit sulfonylurea receptor 1 (SUR1). Causes cell membrane depolarization and opening of voltage-dependent calcium channel. Increases intracellular calcium and stimulates insulin secretion in beta cells NLRP3 inflammasome inhibitor. Broad-spectrum ATP-binding cassette (ABC) transporter inhibitor. Shown to have anti-leishmanial activity. Potential inhibitor of collagenases.

Supplier: Adipogen

Description: Highly potent, selective and reversible cell permeable inhibitor of the proteasome. Inhibits the chymotrypsin-like and caspase-like peptidase activity of the proteasome. Calpain and cathepsin inhibitor. Autophagy activator. Anticancer compound. Inhibits proliferation and migration of several tumor cell lines with nanomolar potency. Apoptosis inducer.