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Catalog Number: (100296-386)
Supplier: Indofine Chemical Company
Description: Lipid Research 100mg Room temperature.

Small Business Enterprise Minority or Woman-Owned Business Enterprise


Catalog Number: (100277-262)
Supplier: Indofine Chemical Company
Description: Rare Organics & BioChemicals 1gm BOC-D-Bta-OH 321.4 Room temperature.

Small Business Enterprise Minority or Woman-Owned Business Enterprise


Catalog Number: (100297-030)
Supplier: Indofine Chemical Company
Description: Fluoro Organics 129322-83-4 5gm 174.12 Room temperature. 99%.

Small Business Enterprise Minority or Woman-Owned Business Enterprise


Catalog Number: (100291-388)
Supplier: Indofine Chemical Company
Description: Lipid Research 5mg 509.90 Room temperature.

Small Business Enterprise Minority or Woman-Owned Business Enterprise


Catalog Number: (100284-972)
Supplier: Indofine Chemical Company
Description: Lipid Research 25mg Room temperature. 98+%.

Small Business Enterprise Minority or Woman-Owned Business Enterprise


Supplier: THE LYNN PEAVEY COMPANY
Description: <p>Easy and clean.</p>

New Product

Supplier: THE LYNN PEAVEY COMPANY
Description: Record full palm or foot prints.

New Product

Catalog Number: (76292-892)
Supplier: Cayman Chemical Company
Description: Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a nucleotidyltransferase located in the cytosol that acts as a cytosolic DNA sensor to detect foreign DNA from microbial pathogens as part of the innate immune response. Upon binding to cytosolic DNA, cGAS produces the cyclic dinucleotide second messenger cGAMP, which activates (STING), leading to activation of the type I interferon (IFN) pathway. <em>In vitro</em>, fibroblasts, macrophages, and dendritic cells isolated from cGAS knockout (cGAS<sup>-/-</sup>) mice do not produce type I IFNs following DNA transfection or DNA virus infection. Similarly, cells containing a frame-shift mutation in the cGAS locus fail to mount an immune response to HIV and other retroviruses. <em>In vivo</em>, cGAS<sup>-/-</sup> mice infected with herpes simplex virus 1 (HSV-1) have lower levels of IFN-α and IFN-β, shorter survival times, and higher post-mortem levels of HSV-1 in the brain.


Catalog Number: (76293-148)
Supplier: Cayman Chemical Company
Description: Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN). The R232 variant is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project.{38697} The SNP variant H232 (Item No. 22815) is found at a 13.7% frequency. Various mutations in STING either reduce or increase its activity. Gain-of-function mutations in STING, including R284M (Item No. 23594) and V155M, lead to constitutive activation and enhancement of the type I IFN response. The V155M mutation is associated with a systemic inflammatory condition, including pulmonary fibrosis and autoimmune factors. Mutations that reduce STING activity include K224R (Item No. 23593), which reduces ubiquitination of STING thereby disrupting its localization within the cell, and the double mutation G230A, R293Q (Item No. 23592), which reduces the IFN response. A T596A mutation present in the mouse strain Goldenticket leads to a complete loss of STING protein and lack of a type I IFN response to infection by <em>Listeria</em>.


Supplier: Cayman Chemical Company
Description: 4'-Methyl-α-pyrrolidinopropiophenone hydrochloride ≥97% analytical standard

Catalog Number: (76544-050)
Supplier: Cayman Chemical Company
Description: A Certified Reference Material


Catalog Number: (76543-960)
Supplier: Cayman Chemical Company
Description: A Certified Reference Material


Catalog Number: (76543-998)
Supplier: Cayman Chemical Company
Description: A Certified Reference Material


Catalog Number: (76544-104)
Supplier: Cayman Chemical Company
Description: A Certified Reference Material


Catalog Number: (76544-174)
Supplier: Cayman Chemical Company
Description: A Certified Reference Material


Catalog Number: (76544-170)
Supplier: Cayman Chemical Company
Description: A Certified Reference Material


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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  • State issued document with your organization's Federal Tax ID Number
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* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. VWR will not lift restrictions for residential shipping addresses.

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