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Catalog Number: (75817-252)
Supplier: Cayman Chemical Company
Description: A colorimetric screening assay for hepatoxicity assessment.


Catalog Number: (75817-230)
Supplier: Cayman Chemical Company
Description: For the measurement of total nitrate/nitrite concentrations.


Catalog Number: (75817-360)
Supplier: Cayman Chemical Company
Description: For the measurement of IgG in mouse plasma, mouse serum, cell culture supernatants, and ascites.


Catalog Number: (75817-140)
Supplier: Cayman Chemical Company
Description: For the measurement of creatinine levels in plasma and serum.


Catalog Number: (75817-130)
Supplier: Cayman Chemical Company
Description: A sensitive tool for measuring free fatty acids in plasma, serum, and urine.


Supplier: Cayman Chemical Company
Description: bis-ANS is a high-affinity non-covalent extrinsic fluorescent dye used to analyze protein conformation. Its predominant interaction with proteins is through its hydrophobic phenyl and naphthyl rings.

Catalog Number: (76293-160)
Supplier: Cayman Chemical Company
Description: STING R224 variant (human recombinant) contains amino acids 138-379 of the wild-type variant (R232) with lysine 224 substituted with arginine. Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN). The R232 variant of STING is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project. The SNP variant H232 is found at a 13.7% frequency. The K224R mutation prevents ubiquitination of STING at position K224, a process which is essential for efficient cytosolic DNA-mediated signaling. Therefore, this mutation disrupts optimal STING trafficking, which inhibits TBK1-mediated IRF3 activation but not NF-κB activation.


Supplier: Cayman Chemical Company
Description: QNZ 98

Supplier: Cayman Chemical Company
Description: Cyclic di-GMP (sodium salt) 95

Catalog Number: (76292-894)
Supplier: Cayman Chemical Company
Description: Cyclic GMP-AMP (cGAMP) synthase (cGAS) (161-522) is a truncated form of cGAS (Item No. 22810) that contains the nucleotidyltransferase and Mab21 domains. cGAS is a nucleotidyltransferase located in the cytosol that acts as a cytosolic DNA sensor to detect foreign DNA from microbial pathogens as part of the innate immune response. Upon binding to cytosolic DNA, cGAS produces the cyclic dinucleotide second messenger cGAMP, which activates stimulator of interferon genes (STING), leading to activation of the type I interferon (IFN) pathway. <em>In vitro</em>, fibroblasts, macrophages, and dendritic cells isolated from cGAS knockout (cGAS<sup>-/-</sup>) mice do not produce type I IFNs following DNA transfection or DNA virus infection. Similarly, cells containing a frame-shift mutation in the cGAS locus fail to mount an immune response to HIV and other retroviruses. <em>In vivo</em>, cGAS<sup>-/-</sup> mice infected with herpes simplex virus 1 (HSV-1) have lower levels of IFN-α and IFN-β, shorter survival times, and higher post-mortem levels of HSV-1 in the brain.


Supplier: Cayman Chemical Company
Description: G10 (Sting antagonist) 98

Supplier: Cayman Chemical Company
Description: BMS 345541 (trifluoroacetate salt) 98

Catalog Number: (76544-626)
Supplier: Cayman Chemical Company
Description: A Certified Reference Material


Catalog Number: (76544-662)
Supplier: Cayman Chemical Company
Description: A Certified Reference Material


Catalog Number: (76544-580)
Supplier: Cayman Chemical Company
Description: A Certified Reference Material


Catalog Number: (76544-674)
Supplier: Cayman Chemical Company
Description: A Certified Reference Material


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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