You Searched For: ADIPOGEN CORP MS

Catalog Number: (102979-194)

Supplier: Adipogen

Description: Unmethylated CG dinucleotides within particular sequence contexts are responsible for the immunostimulatory activity of bacterial DNA. Synthetic oligonucleotides (ODN) that contain such CpG motifs (CpG ODNs) mimic microbial DNA. The innate immune system of vertebrates has the ability to recognize CpG motifs in microbial DNA via the Toll-like receptor (TLR) 9 if the CpG ODN were free of additional immune stimulatory contaminants often present in synthetic commercial CpG ODN preparations designed for molecular biology applications (i.e. PCR). Given that high quality CpG ODNs were used, a close link has been established between the expression of TLR9 on certain immune cell subsets and the modulation of the immune system by CpG DNA. Different types of CpG ODNs were identified based on their differing biological effects on different cell types: ODN Type A is a potent inducer of IFN-alpha in human PDC, (i.e. ODN 1585 or 2216) leading to antigen presenting cell (APC) maturation, whereas ODN Type B (i.e. ODN 2006 or ODN 1668 / ODN 1826) is a weak inducer of IFN-alpha but rather stimulates IL-8 production and increasing costimulatory and Ag-presenting molecules and triggers proliferation of B-cells and IgM and IL-6 production. A third type of CpG ODN has been identified, termed ODN Type C, with both high induction of INF-alpha in PDC and activation of B-cells. The sequence of CpG Type C (also called K) (i.e. ODN 2395 or M362) combines elements of both Type A and Type B and contains a central palindromic sequence with CG dinucleotides, a characteristic feature of Type A, and a TCGTCG motif at the 5' end, present in Type B CpG ODNs. Although the CpG motifs are thought to differ between mice and humans, in both species the recognition of CpG ODNs is mediated by TLR9. The optimal CpG motif in humans is GTCGTT and GACGTT for the murine sequence. However, recent evidence suggests that this sequence specificity is restricted to phosphorothioate (PS)-modified ODN and is not observed when a natural phosphodiester backbone is used. In recent years sequence requirements, specificity, signalling pathways and kinetics of the TLR9 suppression by inhibitory ODNs (iODNs) have been investigated.

Supplier: Adipogen

Description: TNF-R1 is a receptor for TNF-alpha and homotrimeric lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

Catalog Number: (102513-264)

Supplier: Adipogen

Description: Human CD80 (B7-1) is a costimulatory ligand for CD28 and CD152 (CTLA-4). CD80 is expressed on activated B cells.

Supplier: Adipogen

Description: Bifunctional linker for chemical synthesis.

Supplier: Adipogen

Description: The transmembrane and secreted protein delta-like 1 homolog (DLK1; Protein delta homolog 1; Preadipocyte factor 1; Pref-1) belongs to the EGF-like family. It can be cleaved by a tumor necrosis factor-alpha converting enzyme (TACE) to release a soluble form. DLK1 plays important roles in regulating cell differentiation such as adipogenesis and osteogenesis. Membrane-bound DLK1 promotes hypertrophic myotube formation, whereas soluble DLK1 inhibits myotube formation. The soluble form of DLK1 inhibits preadipocyte differentiation, while membrane DLK1 represses preadipocyte proliferation. DLK1 is also associated with tumor invasion.

Catalog Number: (102514-806)

Supplier: Adipogen

Description: FABP4 is a fatty acid binding protein in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs regulate the fatty acid uptake, transport, and metabolism. aP2, the mouse form of FABP4, seems to be central to the pathway that links obesity to insulin resistance. aP2 was shown to be an adipokine linking adipocytes to hepatic glucose production and that neutralizing secreted aP2 may represent an effective therapeutic strategy against diabetes.

Supplier: Adipogen

Description: Lipocalin-2 is an iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development.

Supplier: Adipogen

Description: Antibiotic

Catalog Number: (102513-284)

Supplier: Adipogen

Description: Human CD54 (ICAM-1) mediates cell adhesion by binding to the integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). CD54 expression on resting peripheral blood leukocytes is weak but is upregulated on activated T and B lymphocytes and on monocytes.

Supplier: Adipogen

Description: The reagent, a cyanine dye, can be used as a label for the determination of proteins with NIR-fluorescent technology. The absorption-maxima of the reagent lies in a region of low interference by other biomolecules. The isothiocyanate-moiety is used to link the reagent to proteins which can sensitively be detected. Experiments to lower the detection-limits of immunoassays have been done.

Supplier: Adipogen

Description: Chrysomycin B is a Topoisomerase II inhibitor.

Catalog Number: (102991-132)

Supplier: Adipogen

Description: Building block for synthesis.

Catalog Number: (102513-346)

Supplier: Adipogen

Description: CD127 (IL-7Ra) is the specific receptor component for the cytokine interleukin -7 (IL-7). It is found on a wide variety of hematopoietic cell types including B cell precursors and the majority of T cells. Its expression levels are decreased on T cells following activation. CD127 can dimerize with CD132 (IL-2Rgamma) to form a high affinity IL-7 receptor. CD127 engagement is necessary for T cell development in humans.

Catalog Number: (102515-718)

Supplier: Adipogen

Description: Anticancer compound. Shows antimalarial and antitubercular activity. Cytotoxic against several cancer cell lines. Antibacterial against Gram-positive bacteria and antifungal. Activator of murine T lymphocytes, NK cells and macrophages.

Supplier: Adipogen

Description: Poly(ADP-ribose) polymerase (PARP) inhibitor.

Supplier: Adipogen

Description: Highly water soluble enzyme substrate for the fluorimetric assay of esterases at longwave excitation and emission wavelengths.