You Searched For: Biogems

Catalog Number: (75841-614)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The RPA-2.10 monoclonal antibody specifically binds to human CD2, a 50 kDA type I transmembrane glycoprotein. CD2 is expressed on NK cells, thymocytes, T lymphocytes, and B cell subsets. CD2 is involved in cell-cell adhesion, T cell activation, and T cell signaling. Its ligand is CD58 and it is reported to bind to CD48, CD59, and CD15. The RPA-2.10 antibody is reported to be cross-reactive with pigs and non-human primates..

Catalog Number: (75841-682)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The 17A2 monoclonal antibody specifically reacts with the MouseT lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation. CD3 is expressed by thymocytes and mature lymphocytes, and contains γ, δ, and ε subunits, involved in the assembly, trafficking, and surface expression of T-cell receptor complex. The interaction between the T lymphocytes and the 17A2 antibody can be blocked by the 145-2C11 anti-CD3e antibody, demonstrating that the 17A2 antibody recognizes the CD3 ε chain.

Catalog Number: (75841-694)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The G4.18 monoclonal antibody specifically reacts with rat CD3, a T cell lineage marker and associated with the T cell receptor (TCR). CD3 is involved in antigen recognition, cell activation, and signal transduction and is found on subsets of NK-T, peripheral T, dendritic epidermal T, and thymocyte cells. Immobilized G4.18 antibody activates T cells in vitro and in vivo treatments of the G4.18 antibody prevents cardiac and skin allograft rejection.

Catalog Number: (75841-734)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The 145-2C11 monoclonal antibody reacts with mouse CD3e, the 20 kDa ε chain of the TCR complex. Together with the γ and δ subunits of CD3, the ε subunits are involved in the assembly, trafficking, and surface expression of T-cell receptor complex. CD3 is expressed on thymocytes, mature T cells, and natural killer T cells, and the ε chain enhances the antigen recognition.The 145-2C11 antibody binds to the TCR complex and, depending on the conditions, initiates T cells activation, proliferation, and apoptosis. The soluble antibody seems to block lysis of target cells by antigen-specific cytotoxic T lymphocytes. The 145-2C11 antibody does not cross-react with the rat leukocytes, and it is used as a phenotypic marker for mouse T lymphocytes.

Catalog Number: (75841-736)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The 145-2C11 monoclonal antibody reacts with mouse CD3e, the 20 kDa ε chain of the TCR complex. Together with the γ and δ subunits of CD3, the ε subunits are involved in the assembly, trafficking, and surface expression of T-cell receptor complex. CD3 is expressed on thymocytes, mature T cells, and natural killer T cells, and the ε chain enhances the antigen recognition.The 145-2C11 antibody binds to the TCR complex and, depending on the conditions, initiates T cells activation, proliferation, and apoptosis. The soluble antibody seems to block lysis of target cells by antigen-specific cytotoxic T lymphocytes. The 145-2C11 antibody does not cross-react with the rat leukocytes, and it is used as a phenotypic marker for mouse T lymphocytes.

Catalog Number: (75841-776)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The M1/69 monoclonal antibody specifically reacts with mouse CD24, variably glycosylated GPI-anchored membrane protein. CD24 is known as the Heat Stable Antigen (HAS or HsAG) and is found on epithelial cells, thymocytes, monocytes, erythrocytes, granulocytes, dendritic cells and lymphocytes to the exclusion of NK cells. It is useful in delineating the stages of lymphocyte development and is involved in the costimulation of CD4+ T cells by B cells. CD62P (P-Selectin) is the reported ligand of CD24.

Catalog Number: (75841-884)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The UCHL1 monoclonal antibody specifically reacts with human CD45RO, a 180 kDa isoform of the leukocyte common antigen CD45. CD45RO is a transmembrane glycoprotein with tyrosine phosphatase activity and is expressed by majority of thymocytes, monocytes, granulocytes, and activated memory T lymphocytes. The subsets of peripheral T lymphocytes can be discriminated by using the CD45RO and CD45RA expressing cells.

Catalog Number: (75841-942)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The PC61.5 antibody specifically reacts with mouse CD25, the 55 kDa low-affinity Interleukin-2 Receptor α chain (IL-2R α), expressed on early progenitors of T and B lineage, and on B and T cells. Together with CD122 (IL-2 Receptor β) and CD 132 (IL-2 Receptor γc, the common gamma chain), CD25 forms high-affinity receptor complexes for IL-2. Resting B and T cells and natural killer cells do not express IL-2Rα. Cd25 is also expressed on the dendritic cells, and it enhances lymphocyte differentiation and activation.The PC61.5 antibody blocks the binding of IL-2 to both high-affinity and low-affinity receptors.

Catalog Number: (75841-944)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The PC61.5 antibody specifically reacts with mouse CD25, the 55 kDa low-affinity Interleukin-2 Receptor α chain (IL-2R α), expressed on early progenitors of T and B lineage, and on B and T cells. Together with CD122 (IL-2 Receptor β) and CD 132 (IL-2 Receptor γc, the common gamma chain), CD25 forms high-affinity receptor complexes for IL-2. Resting B and T cells and natural killer cells do not express IL-2Rα. Cd25 is also expressed on the dendritic cells, and it enhances lymphocyte differentiation and activation.The PC61.5 antibody blocks the binding of IL-2 to both high-affinity and low-affinity receptors.

Catalog Number: (75841-930)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The BC96 monoclonal antibody specifically reacts with the 55 kDa type I transmembrane glycoprotein known as the interleukin-2 receptor α (IL-2R α, also known as CD25). CD25 is expressed by the early progenitors of T and B lymphocytes lineage, and by activated mature T and B lymphocytes. CD25 is a low affinity interleukin-2 receptor, but its association with the IL-2 receptor β chain (CD122) and the common γ chain (CD 132) results in a high affinity IL-2R complex. CD25 plays an important role in B and T cell proliferation, differentiation, and activation.

Catalog Number: (75841-936)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The PC61.5 antibody specifically reacts with mouse CD25, the 55 kDa low-affinity Interleukin-2 Receptor α chain (IL-2R α), expressed on early progenitors of T and B lineage, and on B and T cells. Together with CD122 (IL-2 Receptor β) and CD 132 (IL-2 Receptor γc, the common gamma chain), CD25 forms high-affinity receptor complexes for IL-2. Resting B and T cells and natural killer cells do not express IL-2Rα. Cd25 is also expressed on the dendritic cells, and it enhances lymphocyte differentiation and activation.The PC61.5 antibody blocks the binding of IL-2 to both high-affinity and low-affinity receptors.

Catalog Number: (75841-916)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The BC96 monoclonal antibody specifically reacts with the 55 kDa type I transmembrane glycoprotein known as the interleukin-2 receptor α (IL-2R α, also known as CD25). CD25 is expressed by the early progenitors of T and B lymphocytes lineage, and by activated mature T and B lymphocytes. CD25 is a low affinity interleukin-2 receptor, but its association with the IL-2 receptor β chain (CD122) and the common γ chain (CD 132) results in a high affinity IL-2R complex. CD25 plays an important role in B and T cell proliferation, differentiation, and activation.

Catalog Number: (75841-968)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The 30-F11 monoclonal antibody specifically reacts with all isoforms of CD45 and also with the alloantigens CD45.1 and CD45.2 (LCA). CD45 is a transmembrane glycoprotein, expressed by all the hematopoietic cells, except for platelets and mature erythrocytes, which distinguishes the leukocytes from the non-hematopoietic cells. The CD45 molecule is a member of the Protein Tyrosine Phosphatase (PTP) family, because its intracellular region contains two PTP domains. The extracellular region’s variability is caused by different levels of glycosylation, and the splicing of the 4, 5, and 6 exons.The isoforms found in the mouse strains depend on the activation state, maturation stage and cell type, and are very important in B and T lymphocytes antigen receptor signal transduction.

Catalog Number: (75841-976)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The 30-F11 monoclonal antibody specifically reacts with all isoforms of CD45 and also with the alloantigens CD45.1 and CD45.2 (LCA). CD45 is a transmembrane glycoprotein, expressed by all the hematopoietic cells, except for platelets and mature erythrocytes, which distinguishes the leukocytes from the non-hematopoietic cells. The CD45 molecule is a member of the Protein Tyrosine Phosphatase (PTP) family, because its intracellular region contains two PTP domains. The extracellular region’s variability is caused by different levels of glycosylation, and the splicing of the 4, 5, and 6 exons.The isoforms found in the mouse strains depend on the activation state, maturation stage and cell type, and are very important in B and T lymphocytes antigen receptor signal transduction.

Catalog Number: (75841-958)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The PC61.5 antibody specifically reacts with mouse CD25, the 55 kDa low-affinity Interleukin-2 Receptor α chain (IL-2R α), expressed on early progenitors of T and B lineage, and on B and T cells. Together with CD122 (IL-2 Receptor β) and CD 132 (IL-2 Receptor γc, the common gamma chain), CD25 forms high-affinity receptor complexes for IL-2. Resting B and T cells and natural killer cells do not express IL-2Rα. Cd25 is also expressed on the dendritic cells, and it enhances lymphocyte differentiation and activation.The PC61.5 antibody blocks the binding of IL-2 to both high-affinity and low-affinity receptors.

Catalog Number: (75841-872)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The RA3-6B2 monoclonal antibody specifically reacts with a 220 kDa exon A-restricted epitope on the extracellular domain of mouse CD45 glycoprotein. CD45R/B220 is expressed on all the development stages of B cells, and at a low level on plasma cells and a subset of memory B cells. Low levels of CD45R/B220 are also expressed by some activated T lymphocytes, natural killer cell progenitors in the bone marrow, lymphokine activated killer cells (LAK), T lymphocytes of lpr/lpr mutant mouse, apoptotic T cells of mice injected with bacterial superantigens, and macrophage progenitors in fetal liver.The CD45 molecule is a member of the Protein Tyrosine Phosphatase (PTP) family, because its intracellular region contains two PTP domains. The extracellular region’s variability is caused by different levels of glycosylation, and the splicing of the 4, 5, and 6 exons. The isoforms found in the mouse strains depend on the activation state, maturation stage and cell type, and are very important in B and T lymphocytes antigen receptor signal transduction.The RA3-6B2 antibody inhibits in vivo B lymphocytes responses and enhances isotype switching during in vitro B lymphocyte responses.