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Supplier: Peprotech

Description: TECK is a CC chemokine, specifically expressed by thymic stromal cells, and signals through the CCR9 receptor. TECK is chemotactic towards activated macrophages, thymocytes and dendritic cells. Recombinant Human TECK (CCL25) is a 14.2 kDa protein containing 127 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

Catalog Number: (10778-858)

Supplier: Peprotech

Description: The Murine Hematopoietic Stem Cell Expansion Cytokine Package contains the key components required for ex vivo mouse hematopoietic stem cells.

Supplier: Peprotech

Description: Recombinant Human/Murine/Rat Irisin, Purity: Greater than 90% by SDS-PAGE, Source: CHO cells, Cross Reactivity: Human, Mouse, Rat, Synonyms: Fibronectin type III domain-containing protein 5, Fibronectin type III repeat-containing protein 2, Size: 100UG

Supplier: Peprotech

Description: The Insulin/Relaxin structural family of proteins consists of at least seven members, each containing an insulin-like heterodimeric structure of two polypeptide chains held together by two inter-chain disulfide bonds. The INSL5/INSL7 hybrid contains the β-chain of INSL7 (Relaxin-3), linked to the α-chain of INSL5. The INSL5/INSL7 hybrid protein can specifically activate the G protein-coupled receptors, GPCR135 and GPCR142, but unlike Relaxin-3, does not induce significant activation of the LGR7 receptor. Recombinant Human INSL5/INSL7 Hybrid is a heterodimeric, 5.2 kDa protein consisting of a 27 amino acid β-chain linked to a 21 amino acid α-chain by two disulfide bonds.

Catalog Number: (10777-690)

Supplier: Peprotech

Description: PeproTech's Murine IL-4 ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant murine IL-4 in a sandwich ELISA format.

Supplier: Peprotech

Description: IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 are cross-species reactive. Recombinant Human IL-5 is a 26.5 kDa disulfide-linked homodimeric protein containing two 116 amino acid chains.

Supplier: Peprotech

Description: BMPs (Bone Morphogenetic Proteins) belong to the TGF-β superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis, and is expressed in a variety of tissues, including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant Human BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains. Manufactured using all Animal-Free reagents.

Supplier: Peprotech

Description: Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body, and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. PeproTech’s

Supplier: Peprotech

Description: IL-34 is a homodimeric cytokine that is expressed in a range of tissues that include spleen, heart, brain, liver, kidney, lung, ovary, thymus, testis, small intestine, prostate and colon. IL-34 is a ligand for colony-stimulating factor-1 receptor (CSF1R), which also binds to CSF-1. It specifically binds CD14+ monocytes, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. IL-34, like human CSF-1, stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1. Recombinant Human IL-34 is a 52.5 kDa homodimeric glycoprotein consisting of 460 amino acid residues, including a C-terminal His-Tag.

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Supplier: Peprotech

Description: NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4.  These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures.  NT-3 is expressed by neurons of the central nervous systems, and can signal through the trk receptors.  NT-3 promotes the growth and survival of nerve and glial cells.  The amino acid sequences of human, murine and rat NT-3 are identical.  Recombinant Human NT-3 is a noncovalently linked homodimer of two 13.6 kDa polypeptide monomers (240 total amino acid residues). Manufactured using all Animal-Free reagents.

Supplier: Peprotech

Description: Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi’s sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. The human OSM gene encodes for a 252 amino acid polypeptide, containing 25 amino acid signal sequence for secretion and a 227 precursor protein. Proteolytic processing of this precursor removes an 18 amino acid C-terminal peptide and generates the mature OSM form. Recombinant Human Oncostatin M is a 23.6 kDa protein, containing 209 amino acid residues.

Supplier: Peprotech

Description: MIP-3α is a CC chemokine, expressed in the liver, lymph nodes, appendix, PBL and lungs that can signal through the CCR6 receptor. MIP-3α is chemotactic towards lymphocytes and dendritic cells. Additionally, it promotes the adhesion of memory CD4+ T cells, and inhibits colony formation of bone marrow myeloid immature progenitors. Recombinant Human MIP-3α (CCL20) is an 8.0 kDa protein containing 70 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Supplier: Peprotech

Description: Interleukin-1 receptor antagonist (IL-1RA) is a naturally-occurring, inflammatory-inhibitor protein. It inhibits the activity of IL-1α and IL-1β by competitively blocking their binding to type I and type II receptors. IL-1RA is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL-1RA may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Recombinant Human IL-1RA is a 17.2 kDa protein consisting of 153 amino acid residues.

Supplier: Peprotech

Description: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses.

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Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Murine MIP-1α (CCL3). Anti­Murine MIP-1α (CCL3)­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Murine MCP-2 (CCL8). Anti­Murine MCP-2 (CCL8)­specific antibody was purified by affinity chromatography and then biotinylated.