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Catalog Number: (102514-428)
Supplier: Adipogen
Description: GITR is the receptor for TNFSF18. It is involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediates NF-kappaB activation via the TRAF2/NIK pathway.


Catalog Number: (102514-416)
Supplier: Adipogen
Description: The adipocytokine resistin which belongs to a family of cysteine-rich C-terminal proteins known as resistin-like molecules (RELM; RELMalpha/FIZZ 1 and RELMbeta/FIZZ 2) of FIZZ (found in inflammatory zone) are thought to be involved in inflammatory processes. Previous studies in mice showed that resistin impairs glucose tolerance and insulin action. In addition, resistin also inhibits adipogenesis in murine 3T3-L1 cells. Therefore resistin has also been proposed as an adipocyte-secreted factor thought to link obesity and T2DM.


Catalog Number: (102514-354)
Supplier: Adipogen
Description: Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.


Catalog Number: (102513-166)
Supplier: Adipogen
Description: Human CD166 is a type 1 glycoprotein expressed on activated T cells, B cells and monocytes and appears to be the ligand for CD6. Human CD166 may be important for activation of T cells.

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Catalog Number: (102513-172)
Supplier: Adipogen
Description: Human CD45RA is expressed on all cells of hematopoietic origin, except erythrocytes. CD45RA is a transmembrane tyrosine phosphate which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing of exons 4-7 of a single gene coding for the various N-terminal peptide segments. The CD45RA isoform predominates on naive/resting T cells and medullary thymocytes.

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Catalog Number: (102513-202)
Supplier: Adipogen
Description: Human CD252 (CD134L; OX40 ligand) is a type II membrane protein with homology to TNF which is expressed on activated B cells and activated endothelial cells. CD252 binds to CD134 (OX40) present on activated T cells, providing a costimulatory signal. Blockade of this interaction in mouse abrogated immunological effects in several models of inflammation and rejection.

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Catalog Number: (102512-444)
Supplier: Adipogen
Description: Human CD54 (ICAM-1) mediates cell adhesion by binding to the integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). CD54 expression on resting peripheral blood leukocytes is weak but is upregulated on activated T and B lymphocytes and on monocytes.

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Catalog Number: (102512-418)
Supplier: Adipogen
Description: Human CD50 (ICAM-3) is an adhesion molecule that interacts with LFA-1 (CD18/CD11a) and provides a costimulatory signal for T cells which is thought to be essential for initiation of immune responses.

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Catalog Number: (102512-858)
Supplier: Adipogen
Description: Human CD79b is the B cell antigen receptor Ig beta chain (BCR-Ig beta) which associates with B cell antigen receptor Ig alpha chain to form a functional heterodimer that interacts with membrane immunoglobulin (mIg) (3). The mIgM component binds antigen and the Ig alpha/Ig beta heterodimer transduces signals. Analysis of CD79b expression is useful in diagnosis of B cell lymphoproliferative disorders.

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Catalog Number: (102512-834)
Supplier: Adipogen
Description: Immunoglobulin expressed by the mouse plasmacytoma TEPC 183 is an IgMkappa isotype of unknown binding specificity. It is used as a negative control when working with human cells.

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Catalog Number: (102511-958)
Supplier: Adipogen
Description: Human CD8 is a heterodimeric protein consisting of an alpha and beta chain, each about 33kDa. CD8 is expressed on most thymocytes and on about one third of peripheral blood T cells. CD8 is a co-receptor involved in antigen recognition and binds to the alpha2 and alpha3 domain of MHC Class I molecules.

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Catalog Number: (102511-956)
Supplier: Adipogen
Description: Human CD8 is a heterodimeric protein consisting of an alpha and beta chain, each about 33kDa. CD8 is expressed on most thymocytes and on about one third of peripheral blood T cells. CD8 is a co-receptor involved in antigen recognition and binds to the alpha2 and alpha3 domain of MHC Class I molecules.

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Catalog Number: (102511-950)
Supplier: Adipogen
Description: Human CD8 is a heterodimeric protein consisting of an alpha and beta chain, each about 33kDa. CD8 is expressed on most thymocytes and on about one third of peripheral blood T cells. CD8 is a co-receptor involved in antigen recognition and binds to the alpha2 and alpha3 domain of MHC Class I molecules.

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Catalog Number: (102511-946)
Supplier: Adipogen
Description: Human CD7 is one of the earliest T lineage markers and is found on most thymocytes and peripheral blood T cells. The function of CD7 is not yet fully known, although cross-linking of CD7 with antibodies induces a T cell transmembrane calcium flux and CD7 expression is induced by ionomycin.

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Catalog Number: (102511-930)
Supplier: Adipogen
Description: Human CD6 is expressed on peripheral blood T cells, most thymocytes and a subset of B cells. CD6 is similar to CD5 and contains three cysteine-rich domains with structural homology to the macrophage scavenger receptor. CD6 is involved in T cell activation and its ligand was recently identified.

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Catalog Number: (102511-904)
Supplier: Adipogen
Description: Human CD4 is a cell surface glycoprotein of 55kDa expressed on most thymocytes, on about two thirds of peripheral T cells and on some monocyte macrophage lineage cells. CD4 interacts with MHC Class II molecules in an accessory role during foreign antigen recognition by T cells. The extracellular portion of CD4 is an array of four Ig-like domains. The N-terminal region of CD4 is a receptor for the HIV-1 viral protein gp120.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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