You Searched For: STEMCELL Technologies

Catalog Number: (MSPP-17531)

Supplier: STEMCELL Technologies

Description: Density gradient medium.

New Product

Catalog Number: (MSPP-100-0784)

Supplier: STEMCELL Technologies

Description: cGMP, human T cell activation and expansion reagent.

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Catalog Number: (MSPP-100-1336)

Supplier: STEMCELL Technologies

Description: Interferon alpha 1 (IFNA1) belongs to the type 1 interferon family of cytokines, which bind interferon alpha receptors (IFNAR; composed of IFNAR1 and IFNAR2 subunits) that are involved in interferon-induced JAK-STAT signaling (Shemesh <i>et al.</i>). Interferons have inhibitory effects on viral replication and pathogenesis, and studies have found that IFN alpha can prevent the spread of herpes simplex virus (HSV) (Mikloska and Cunningham), and human immunodeficiency virus (HIV) (George and Mattapallil). Pegylated forms of IFN alpha are currently approved for the treatment of chronic hepatitis B (Woo <i>et al.</i>). IFN alpha also displays anti-tumor effects by regulating cell growth and proliferation, and it is used in the treatment of different cancers (Tagliaferri <i>et al.</i>). Interferons display alpha-helical structures with four helices forming an antiparallel alpha-helix bundle (Walter). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, interferon alpha 1 from STEMCELL comes lyophilized with ≥90% purity, specific activity EC50 ≤40 to 200 pg/ml, and LAL analysis verification ensuring endotoxin levels are ≤1.0 EU/μg protein.

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Catalog Number: (MSPP-781651006)

Supplier: STEMCELL Technologies

Description: Interferon gamma-inducible protein (IP) 10 or CXCL10 is a member of the CXC chemokine family. It binds CXCR3 activating ERK1/2, p38/MAPK, JNK, and PI3-kinase/AKT signaling pathways, inducing intracellular calcium influx, DNA synthesis, cell proliferation, and chemotaxis. IP-10 regulates innate and adaptive immune responses by affecting the function of activated T cells, natural killer cells, inflammatory dendritic cells, macrophages, and B cells. IP-10 is produced by leukocytes, activated neutrophils, eosinophils, monocytes, epithelial cells, endothelial cells, fibroblasts, and keratinocytes in response to IFN-gamma. IP-10 has been implicated in a wide range of diseases, including infectious diseases and chronic inflammatory and autoimmune diseases, as well as in tumor formation (Liu <i>et al.</i>).

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Catalog Number: (MSPP-100-0215)

Supplier: STEMCELL Technologies

Description: Serum-free culture medium kit for differentiation of human PSCs to atrial cardiomyocytes.

Catalog Number: (MSPP-10989)

Supplier: STEMCELL Technologies

Description: Supplement for the maturation of human monocyte-derived dendritic cells.

Supplier: STEMCELL Technologies

Description: Immunodensity isolation of untouched circulating tumor cells.

Supplier: STEMCELL Technologies

Description: Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes the proliferation and differentiation of hematopoietic progenitor cells and the generation of neutrophils, eosinophils, and macrophages. In synergy with other cytokines such as stem cell factor, IL-3, erythropoietin, and thrombopoietin, it also stimulates erythroid and megakaryocyte progenitors (Barreda <i>et al.</i>). GM-CSF is produced by multiple cell types, including stromal cells, Paneth cells, macrophages, dendritic cells (DCs), endothelial cells, smooth muscle cells, fibroblasts, chondrocytes, and Th1 and Th17 T cells (Francisco-Cruz <i>et al.</i>). The receptor for GM-CSF (GM-CSFR) is composed of two subunits: the cytokine-specific α subunit (GMRα; CD116) and the common subunit βc (CD131) shared with IL-3 and IL-5 receptors (Broughton <i>et al.</i>). GM-CSFR is expressed on hematopoietic cells, including progenitor cells and immune cells, as well as non-hematopoietic cells. Recombinant human GM-CSF (rhGM-CSF) promotes the production of myeloid cells of the granulocytic (neutrophils, eosinophils and basophils) and monocytic lineages <i>in vivo</i>. It has been tested for mobilization of hematopoietic progenitor cells and for treating chemotherapy-induced neutropenia in patients. GM-CSF is able to stimulate the development of DCs that ingest, process, and present antigens to the immune system (Francisco-Cruz <i>et al.</i>). This product is animal component-free.

Catalog Number: (MSPP-17965)

Supplier: STEMCELL Technologies

Description: Immunomagnetic negative selection kit.

Catalog Number: (MSPP-09915)

Supplier: STEMCELL Technologies

Description: Supplement for the expansion and differentiation of lymphoid progenitor cells.

Supplier: STEMCELL Technologies

Description: Nerve growth factor (NGF)-beta is a prototypical member of the neurotrophin family and has a role in the survival and growth of neural cells, regulating cell growth, promoting differentiation into neurons, and neuron migration. The beta subtype of NGF is biologically active in comparison to the alpha-2 and gamma-2 subtypes. NGF-beta in its secreted form can bind to tyrosine kinase A (TrkA) receptor with high affinity and to p75 (NTR) with low affinity (Levi and Alemà; Sofroniew <i>et al.</i>). NGF has been shown to possess pro-inflammatory and pro-fibrogenic properties (Micera <i>et al.</i>). It has also been shown that overexpression of NGF-beta promotes differentiation of bone marrow mesenchymal stem cells into neurons through regulation of AKT and MAPK pathways (Yuan <i>et al.</i>).

New Product

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD16, unconjugated.

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Catalog Number: (MSPP-05701)

Supplier: STEMCELL Technologies

Description: Supplement for expansion of mouse and rat neural stem and progenitor cells.

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Catalog Number: (MSPP-100-1626)

Supplier: STEMCELL Technologies

Description: Rat monoclonal antibody against mouse CD86 (B7-2), FITC-conjugated.

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Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1, antibody against human, chimpanzee CD4, APC-conjugated.

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Supplier: STEMCELL Technologies

Description: cGMP, enzyme-free cell dissociation reagent.

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