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Tacrolimus >99%

Supplier: Selleck Chemicals
Description: Tacrolimus is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin creating a new complex.

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Clofarabine 99.5%

Supplier: Selleck Chemicals
Description: Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.

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Alisertib 99%

Supplier: Selleck Chemicals
Description: Alisertib (MLN8237) is a selective aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay

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Y-27632 dihydrochloride ≥99.97% (by HPLC)

Supplier: Selleck Chemicals
Description: Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with K<sub>i</sub> of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.

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Thiazovivin

Supplier: Selleck Chemicals
Description: Thiazovivin is a novel ROCK inhibitor with IC50 of 0.5 μm in a cell-free assay, promotes hESC survival after single-cell dissociation.

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Plerixafor (AMD3100)

Supplier: Selleck Chemicals
Description: Plerixafor (AMD3100) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively.

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β-Sitosterol ~97% (by HPLC)

Supplier: Selleck Chemicals
Description: β-Sitosterol is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol.

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Nebivolol hydrochloride ≥99.4%

Supplier: Selleck Chemicals
Description: Nebivolol HCl selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM.

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HPI-4 (Ciliobrevin A), Powder

Supplier: Selleck Chemicals
Description: HPI-4 (Ciliobrevin A) is a hedgehog (Hh) pathway antagonist. It blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo.

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Astragaloside A

Catalog Number: (101756-740)
Supplier: Selleck Chemicals
Description: Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from <i>Astragalus membranaceus</i>, which has been widely used for the treatment of cardiovascular diseases.
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MG-132

Supplier: Selleck Chemicals
Description: MG-132 is a potent cell-permeable inhibitor of proteasome and calpain with an IC<sub>50 </sub>of 100 nM.

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MLN-9708

Supplier: Selleck Chemicals
Description: MLN9708 gets hydrolyzed to its biologically active form MLN2238, on exposure to aqueous solutions or plasma

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Linezolid (synthetic)

Catalog Number: (101760-102)
Supplier: Selleck Chemicals
Description: Linezolid (Zyvox) is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics
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GSK1120212 ~99.5%

Supplier: Selleck Chemicals
Description: Trametinib is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2.

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Tadalafil

Catalog Number: (101763-000)
Supplier: Selleck Chemicals
Description: Tadalafil is a PDE-5 inhibitor with IC<sub>50</sub> of 1.8 nM.
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Pimamicin ~99%

Supplier: Selleck Chemicals
Description: Pimaricin ( synonym Natamycin), a natural and versatile anti-fungal agent during fermentation by the bacterium <i>Streptomyces natalensis</i>, commonly found in soil, with little to no flavour interference.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
To process your orders without delay, please provide the required business documentation to purchase this product.

To order chemicals, medical devices, or other restricted products please provide ID that includes your business name & shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number. Acceptable forms of ID are:

  • State issued document with your organization's Federal Tax ID Number
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  • City or County issued Business License
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  • Any other ID issued by the State that includes the business name & address

* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. VWR will not lift restrictions for residential shipping addresses.

-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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