Toxoplasma gondii Recombinant Profilin (from Escherichia coli)

Supplier: ADIPOGEN CORP MS

AG-40B-0121-C010 AG-40B-0121-3010

102980-208EA 290.77 USD

102980-208 102980-210

Toxoplasma gondii Recombinant Profilin (from Escherichia coli)

Proteins and Peptides

TLR11, an innate sensor for profilin (Toxoplasma gondii), is an intracellular receptor that resides in the endoplasmic reticulum. The 12 membrane-spanning endoplasmic reticulum-resident protein UNC93B1 interacts directly with TLR11 and regulates the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12, a previously uncharacterized TLR, also recognizes profilin from Toxoplasma gondii. TLR12 is sufficient for recognition of profilin by plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both required in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice succumb rapidly to T. gondii infection.

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