N-Hydroxy-N'-phenyloctanediamide

Supplier: ADIPOGEN CORP MS

Synonyms: N1-Hydroxy-N8-phenyloctanediamide, Suberoylanilide Hydroxamic Acid, Vorinostat

SYN-3006-M005 SYN-3006-M010 SYN-3006-M050

102992-854EA 59.54 USD

102992-854 102992-856 102992-858

N-Hydroxy-N'-phenyloctanediamide

N-Hydroxy-N'-phenyloctanediamide

Vorinostat (SAHA, MK0683, Zolinza) inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II) at nanomolar concentrations (IC50 86 nM). These enzymes catalyze the removal of acetyl groups from the lysine residues of histones proteins. In some cancer cells, there is an overexpression of HDACs, or an aberrant recruitment of HDACs to oncogenic transcription factors causing hypoacetylation of core nucleosomal histones. By inhibiting histone deacetylase, vorinostat causes the accumulation of acetylated histones and induces cell cycle arrest and/or apoptosis of some transformed cells. The mechanism of the antineoplastic effect of vorinostat has not been fully characterized.

Formula: C₁₄H₂₀N₂O₃
MW: 264.33 g/mol

MDL Number: MFCD00945317
CAS Number: 149647-78-9

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