Manumycin A (from Streptomyces parvulus) ≥96% (by HPLC)

Supplier: ADIPOGEN CORP MS

BVT-0091-M001 BVT-0091-M005

102513-526EA 131.54 USD

102513-526 102513-528

Manumycin A (from Streptomyces parvulus) ≥96% (by HPLC)

Manumycin A

Manumycin A is a potent, selective and competitive cell permeable rasfarnesyltransferase inhibitor (IC50 = 30 nM).

Antibiotic
Does not affect geranylgeranyltransferase
Neutral sphingomyelinase inhibitor

Antibiotic. Does not affect geranylgeranyltransferase (IC50 = 180 µM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Neutral sphingomyelinase inhibitor. Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19 µM).

Yellow to brown powder

After reconstitution protect from light at -20°C. Stable for at least one year after receipt when stored at -20°C.

Soluble in DMSO or methanol; insoluble in water

Formula: C₃₁H₃₈N₂O₇
Storage Temperature: Freezer

MDL Number: MFCD00920782
CAS Number: 52665-74-4

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