DMS (Dimethyl suberimidate dihydrochloride), Pierce™
Supplier: LIFE TECHNOLOGIES MS
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Warning
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Thermo Scientific Pierce DMS is dimethyl suberimidate, a membrane-permeable crosslinker that contains an amine-reactive imidoester group at each end of an 8-atom spacer arm.
- Reactive groups: imidoester (both ends)
- Reactive towards: amino groups (primary amines)
- Longest of three similar imidoester crosslinkers, which include DMA, DMP and DMS
- Water-soluble
- Imidoesters react with amines at alkaline pH values (pH 8-10) to form amidine bond
- Amidine bond retains net charge character of protein primary amine to which it reacts
- Reversible at high pH values
- Tool for study of quarternary structure of proteins
Caution: For Research Use Only. Not for use in diagnostic procedures.
Formula:
C₁₀H₂₀N₂O₂ Storage Temperature: Refrigerator |
MDL Number:
MFCD00012574 CAS Number: 34490-86-3 |
Specification Test Results
Product Line | Pierce™ |
Labeling Method | Chemical Labeling |
Crosslinker Type | Homobifunctional |
Reactive Moiety | Imidoester |
Spacer | Mid-Length |
Form | Powder |
Quantity | 1 g |
Type | Crosslinker |
Solubility | Water |
Spacer Arm | 11.0 Å |
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