HiLyte™ Fluor 488 hydroxylamine, HCl salt single isomer fluorescent dye

Supplier: Anaspec Inc

AS-64348

103006-524EA 637.23 USD

103006-524

HiLyte™ Fluor 488 hydroxylamine, HCl salt single isomer fluorescent dye

HiLyte™ Fluor

HiLyte™ Fluor 488 hydroxylamine is a carbonyl-reactive labeling dye, which reacts more readily with aldehydes at physiological pH than other primary amine-containing reagents (such as hydrazides and amines).

Spectral Properties Abs/Em = 498/525 nm
Solvent System DMF or DMSO
Storage -20°C desiccated and protected from light

The reaction of HiLyte™ Fluor 488 hydroxylamine with aldehydes yields oxime ethers, which are stable at physiological conditions. Therefore, HiLyte™ Fluor 488 hydroxylamine can be used to directly detect aldehydes in proteins and DNA.

Extinction Coefficient (M-1cm-1): 70,000
Fluorescence quantum yield: 0.91
Fluorescence Life Time (ns): 4.1

ReferencesD. Boturyn, et al, Tetrahedron, 53, 5485 (1997); J. G. Hecker, et al, ChemmedChem, 3, 1356 (2008); Y. Zeng, et al, Nature methods, 6, 207 (2009).

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