390 MMP FRET Substrate IV, Mca-DNP

Supplier: Anaspec Inc

AS-27109

102996-792EA 726.38 USD

102996-792

390 MMP FRET Substrate IV, Mca-DNP

Proteins and Peptides

Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This substrate is readily hydrolyzed by MMP-8, 9 and collagenase-3 (MMP-13), Abs/Em = 325/393 nm. The hydrolysis is inhibited in a 1:1 stoichiometric fashion by the tissue inhibitors of metalloproteinases, TIMP-1, TIMP-2, and TIMP-3.
Sequence:Mca-P-Cha-G-Nva-HA-Dap(Dnp)-NH2
MW:1100.2 Da
% peak area by HPLC:95
Storage condition:-20° C

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