Human Big Gastrin-1

Supplier: Anaspec Inc

AS-20747

102996-108EA 486.69 USD

102996-108

Human Big Gastrin-1

Proteins and Peptides

Big Gastrin is also referred to as Gastrin-34. Secretion of gastrin is induced by food intake and causes the release of gastric acid in the stomach. Secreted by the G cells in the gastric mucosa, it is one of the major bioactive forms of gastrin found in tissue and plasma (the other bioactive form is gastrin-17 or little gastrin - Cat# AS-20750). Both gastrin-17 and gastrin-34 are carboxy-amidated and partially tyrosine sulfated. Binding of gastrin to the CCK2/gastrin receptor requires carboxy-amidation, however sulfation is not necessary for binding to the receptor. Binding of Gastrin to the CCK2/gastrin receptors on parietal cells of the stomach causes them to secrete hydrochloric acid (HCl) and stimulates lectin-like protein Reg expression via activation of PKC and RhoA. Gastrin also plays a role in release of Histamine and Pepsinogen.
Sequence: Pyr-LGPQGPPHLVADPSKKQGPWLEEEEEAYGWMDF-NH2
MW: 3849.3 Da
% Peak area by HPLC: 95
Storage condition: -20° C

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