Polyinosinic-polycytidylic acid potassium salt ≥99% endotoxin-free
Supplier: ADIPOGEN CORP MS
Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. Toll-like receptor 3 (TLR3), melanoma differentiation-associated gene 5 (MDA5), and retinoic acid-inducible gene-I (RIG-I), all sensors of double-stranded RNA (dsRNA) are potent inducers of antiviral activity. dsRNA sensor activation -e.g. by poly (I:C)- induces pro-inflammatory TNF-alpha and antiviral IFN-beta, but can also enhance the expression of pro-apoptotic proteins. Recently, poly (I:C)-induced cell death recently gained considerable attention as a tool to study the 'Ripoptosome' or 'Necrosome' complex, a novel intracellular signaling complex, thought to induce regulated necrosis, also called 'Necroptosis'.
Formula:
(C10H10N4NaO7P)x·(C9H11N3NaO7P)x Storage Temperature: Refrigerator |
CAS Number:
31852-29-6 |
Specification Test Results
Purity |
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Formulation | Lyophilized. Sterile. |
Endotoxin |
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