Mouse Recombinant Megaapril (from HEK293 cells)

Supplier: ADIPOGEN CORP MS

AG-40B-0035-C010 AG-40B-0035-3010
102515-480EA 429.23 USD
102515-480 102515-482
Mouse Recombinant Megaapril (from HEK293 cells)
Proteins and Peptides

APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the NH2 terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.

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