Anti-CD8 alpha Rat Monoclonal Antibody (Biotin) [clone: 53-6.7]

Supplier: Southern Biotechnology

1550-08

100243-174EA 224.92 USD

100243-174

Anti-CD8 alpha Rat Monoclonal Antibody (Biotin) [clone: 53-6.7]

Antibodies

In the mouse, CD8 exists in two forms – (i) a CD8 heterodimer composed of an α chain (CD8α) and a β chain (CD8β); and (ii) a homodimer of two α chains. The heterodimer is found on the surface of essentially all thymocytes and the “suppressor/cytotoxic” subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8α without CD8β. It has been suggested that CD8+β- T cells mature extrathymically, while development of the CD8α+β+ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8α+ cells. The 53-6.7 monoclonal antibody also blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2.

Type: Primary
Antigen: CD8alpha
Clonality: Monoclonal
Clone: 53-6.7
Conjugation: Biotin
Epitope:
Host: Rat
Isotype: IgG2a
Reactivity: Mouse

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