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Description: Kallistatin is a serine proteinase inhibitor which binds to tissue kallikrein and inhibits its amidolytic and kininogenase activity. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein. Heparin blocks kallistatin's complex formation with tissue kallikrein and abolishes its inhibitory effect on tissue kallikrein's activity.
Catalog Number: 10423-552
Supplier: Bioss


Description: Kallistatin is a serine proteinase inhibitor which binds to tissue kallikrein and inhibits its amidolytic and kininogenase activity. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein. Heparin blocks kallistatin's complex formation with tissue kallikrein and abolishes its inhibitory effect on tissue kallikrein's activity.
Catalog Number: 10423-542
Supplier: Bioss


Description: Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.
Catalog Number: 10666-100
Supplier: Bioss


Description: Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.
Catalog Number: 10666-098
Supplier: Bioss


Description: Potent, cell permeable and selective, reversible proteasome inhibitor. Blocks degradation of short-lived proteins and induces a heat shock response. NF-kappaB activation inhibitor through IkappaB degradation. Cell permeable, reversible peptide aldehyde inhibitor. Calpain and cathepsin inhibitor. Has anticancer properties by inducing cell cycle arrest and activating apoptosis in various cancer cell lines. Has adjuvant/chemosensitizer potential. Neurite outgrowth stimulator in PC12 cells. Prevents beta-secretase cleavage. Autophagy activator.
Catalog Number: 102988-460
Supplier: Adipogen


Description: The KingFisher™ Flex series enables highly versatile, automated magnetic particle processing for DNA, RNA, protein, or cell purification from a wide array of sources, including blood, cell cultures, tissue lysates, soil, and feces.
Catalog Number: 95041-912
Supplier: LIFE TECHNOLOGIES CORP


Description: The Chromaster HPLC system has established new limits in performance, ease of use, and robustness. Its design incorporates an extremely low dwell volume and a very low carry-over. In combination with very sensitive detector technology, especially the fluorescence detector, the Chromaster HPLC system is one of the strongest LC systems on the market. A huge amount of accessories and a modular set-up, enable an easy adaption to all customer needs, whether if it is used for an aggressive industrial or a high sensitive pharma application. VWR's relationship with Hitachi started over 30 years ago as a Merck Hitachi cooperation. During this time, the robustness and reliability of the Hitachi HPLC instruments has helped to build and develop a strong partnership.
Catalog Number: 76493-026
Supplier: HITACHI HIGH-TECH AMERICA, INC.


Description: Tube strips consist of eight 0,2 ml thin wall PP tubes connected together. Dual connectors between adjacent tubes eliminate inadvertent breakage during sample handling. Tube strips are designed for precise fit in thermal cyclers to optimize heat transfer. Thermowell® GOLD cap strips are sold separately. Tube strips are tested and certified to be free of DNase/RNase contamination and are autoclavable to 121 °C.
Catalog Number: 33502-084
Supplier: Corning

Description: Plasmodium falciparum is a protozoan parasite that causes malaria. It exhibits considerable antigenic heterogeneity which may be a major problem in developing an effective vaccine against malaria. The S-antigen of Plasmodium falciparum is a highly diverse, heat stable protein that is located in the parasitophorous vacuole of the mature asexual intraerythrocytic parasite. The S-antigen gene consists of multiple alleles that originate from the same chromosome site. The amino acid sequence of each allele contains a large central section of tandemly arranged, nearly identical peptides that are specific to each allele. Thus, directed against the repeat region of a particular allele can be used to define the serotype of an S-antigen. Flanking the central repeat block are two short regions of non-repetitive sequence which occur in four different forms, each of which is utilized to define a single S-antigen family. Comparison of the four S-antigen families reveals t hat they differ considerably from each other with variation being most pronounced in the C-terminal-flanking region.
Catalog Number: 10271-384
Supplier: Bioss


Description: StarFish MonoBlocks are single blocks with multiple wells of the same size; they are ideal for experiments that use the same size/type vessel
Catalog Number: 47800-020
Supplier: Heidolph NA, LLC


Description: StarFish PolyBlocks are "pie-shaped" segments that you can mix and match (up to five) to accommodate various types/sizes of vessels on the same plate
Catalog Number: 47800-044
Supplier: Heidolph NA, LLC


Description: PP plates, silicone mats. Designed to fit 0.2 ml thermal cycler blocks.
Catalog Number: 10011-228
Supplier: Corning

Description: For a high PCR workload, the Eppendorf® Mastercycler nexus X2 offers efficiency with two blocks (32-well and 64-well), allowing simultaneous runs of two independent protocols. Accommodates a range of consumables up to 0.5 ml tubes. For increased capacity, connect with up to three additional units.
Catalog Number: 10119-844
Supplier: Eppendorf


Description: Thick, full, resilient bristles are ideal for pushing sawdust, glass and electronic parts debris.
Catalog Number: 89125-948
Supplier: Janitorial Supplies


Description: SYRO HEATING BLOCK INSTALLATION (FIELD U
Catalog Number: 102975-610
Supplier: Biotage


Description: HEATING BLOCK RND BTM 6.5MM DIA 12X13MM
Catalog Number: 76263-930
Supplier: G-Biosciences


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