Human Recombinant M-CSF (from E. coli)

Supplier: VWR International

Human Recombinant M-CSF (from <italic>E. coli</italic>)

Human Recombinant M-CSF (from <italic>E. coli</italic>)

77753-398 77753-400 77753-402

77753-398EA 3047.68 USD

77753-398 77753-400 77753-402

Human Recombinant M-CSF (from E. coli)

Proteins and Peptides

Macrophage colony-stimulating factor (M-CSF) is a hematopoietic growth factor with broad production across different cell types (1). The regulation of monocyte and macrophage development to maintain homeostasis is primarily governed by M-CSF, which is generated by stromal cells present in both the bloodstream and tissues. Mature mononuclear phagocytes, in response, possess CSF-1 receptors (CSF-1R) and eliminate circulating CSF-1. This process creates a feedback mechanism responsible for diminishing monocyte proliferation (2, 3, 4). M-CSF also exerts its effects by interacting with CSF1R, influencing various processes related to immunology, bone health, fertility, and pregnancy regulation (5). Human M-CSF has cross reactivity to mouse cells, whereas mouse M-CSF does not exhibit activity on human cells (6).

High quality
Low endotoxin
Lot-to-lot consistency
Animal free
Manufactured following GMP guidelines

Host cell protein: ≤30 ng/ml, host cell DNA: ≤0.01 ng/ml, sterility testing: no growth, mycoplasma: negative.

Caution: For research use or further manufacturing only.

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