Tris(hydroxymethyl)aminomethane (TRIS, Trometamol), EMPROVE® ESSENTIAL Ph. Eur., BP, JPC, USP, SAFC®

Supplier: MilliporeSigma

Synonyms: 2-Amino-2-(hydroxymethyl)propane-1,3-diol(tris), Tromethamine, Tris(hydroxymethyl)methylamine, 2-Amino-2-(hydroxymethyl)propane-1,3-diol, 2-Amino-2-(hydroxymethyl)-1,3-propanediol, Trizma(R) base, TRIS base, THAM

1.08386.1000 1.08386.5000 1.08386.9025
EM1.08386.1000EA 634 USD
EM1.08386.1000 EM1.08386.5000 EM1.08386.9025
Tris(hydroxymethyl)aminomethane (TRIS, Trometamol), EMPROVE® ESSENTIAL Ph. Eur., BP, JPC, USP, SAFC®
Tris(hydroxymethyl)aminomethane (TRIS, Trometamol)

Hygroscopic. Endotoxin tested. Filtered through a 0.45µm element. Soluble in water. Toxic effects.


Hygroscopic. Endotoxin tested. Filtered through a 0.45 µm element. Soluble in water. Toxic effects.

Formula: NH₂C(CH₂OH)₃
MW: 121.14 g/mol
Boiling Pt: 357 °C (1013 hPa)
Melting Pt: 169…172 °C
Density: 1.328 g/cm³ (20 °C)
Storage Temperature: Ambient
MDL Number: MFCD00004679
CAS Number: 77-86-1
EINECS: 201-064-4
Merck Index: 13,09842
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Specification Test Results

Assay (acidimetric; calculated on dried substance) 99.0-100.5%
Appearance of solution (5%, water) Passes test
Arsenic (As) 0.00002% max
Chloride (Cl) 0.001% max
Colony count, aerobic bacteria 100CFU/g max
Colony count, yeast and mold 100CFU/g max
Endotoxins 0.03I.U./mg max
Escherichia coli Absent in 10 g
Filtration test (0.45 µm) Conforms
Heavy metals (as Pb) 0.0010% max
Identification A Passes test
Identification B Passes test
Identification C Passes test
Iron (Fe) 0.0010% max
Loss on drying (105°C) 0.5% max
Melting point 168-172°C
Organic volatile impurities (USP/NF) Conforms
Other Residual Solvents (Ph.Eur./ICH) Excluded by production process
pH (5%, water) 10.0-11.5
pH of a 1% aqueous solution 10.3-10.7
Pseudomonas Aeruginosa Absent in 10 g
Related substances (TLC) Conforms
Residual solvents (Ph.Eur./ICH) class 3 0.5% max
Salmonella Absent in 10 g
Staphylococcus Aureus Absent in 10 g
Sulfate (SO4) 0.005% max
Sulfated ash 0.1% max

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