Tris(hydroxymethyl)aminomethane (TRIS, Trometamol), EMPROVE® ESSENTIAL Ph. Eur., BP, JPC, USP, SAFC®
Supplier: MilliporeSigma
Synonyms:
2-Amino-2-(hydroxymethyl)propane-1,3-diol(tris), Tromethamine, Tris(hydroxymethyl)methylamine, 2-Amino-2-(hydroxymethyl)propane-1,3-diol, 2-Amino-2-(hydroxymethyl)-1,3-propanediol, Trizma(R) base, TRIS base, THAM
1.08386.1000
1.08386.5000
1.08386.9025
EM1.08386.1000EA
634
USD
EM1.08386.1000
EM1.08386.5000
EM1.08386.9025
Tris(hydroxymethyl)aminomethane (TRIS, Trometamol), EMPROVE® ESSENTIAL Ph. Eur., BP, JPC, USP, SAFC®
Tris(hydroxymethyl)aminomethane (TRIS, Trometamol)
Hygroscopic. Endotoxin tested. Filtered through a 0.45µm element. Soluble in water. Toxic effects.
Hygroscopic. Endotoxin tested. Filtered through a 0.45 µm element. Soluble in water. Toxic effects.
Formula:
NH₂C(CH₂OH)₃ MW: 121.14 g/mol Boiling Pt: 357 °C (1013 hPa) Melting Pt: 169…172 °C Density: 1.328 g/cm³ (20 °C) Storage Temperature: Ambient |
MDL Number:
MFCD00004679 CAS Number: 77-86-1 EINECS: 201-064-4 Merck Index: 13,09842 |
Specification Test Results
Assay (acidimetric; calculated on dried substance) | 99.0-100.5% |
Appearance of solution (5%, water) | Passes test |
Arsenic (As) | 0.00002% max |
Chloride (Cl) | 0.001% max |
Colony count, aerobic bacteria | 100CFU/g max |
Colony count, yeast and mold | 100CFU/g max |
Endotoxins | 0.03I.U./mg max |
Escherichia coli | Absent in 10 g |
Filtration test (0.45 µm) | Conforms |
Heavy metals (as Pb) | 0.0010% max |
Identification A | Passes test |
Identification B | Passes test |
Identification C | Passes test |
Iron (Fe) | 0.0010% max |
Loss on drying (105°C) | 0.5% max |
Melting point | 168-172°C |
Organic volatile impurities (USP/NF) | Conforms |
Other Residual Solvents (Ph.Eur./ICH) | Excluded by production process |
pH (5%, water) | 10.0-11.5 |
pH of a 1% aqueous solution | 10.3-10.7 |
Pseudomonas Aeruginosa | Absent in 10 g |
Related substances (TLC) | Conforms |
Residual solvents (Ph.Eur./ICH) class 3 | 0.5% max |
Salmonella | Absent in 10 g |
Staphylococcus Aureus | Absent in 10 g |
Sulfate (SO4) | 0.005% max |
Sulfated ash | 0.1% max |
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