Zeta Plus™ BC Series Filter Capsule with DEL Series Media incorporates lipid-specific adsorbents that help reduce lipids, surfactants and other biological contaminants from human blood plasma, serum-based products, recombinant proteins and other biological fluids.
- May help reduce undesirable lipids, lipoprotein haze, and microbial and particulate contaminants
- Full range of cartridge filter sizes to enable laboratory to full-scale production operation
- Totally-enclosed, sanitary-design cartridge vessels makes for easy cleanup, rapid assembly and take down
- All product components comply with United States Pharmacopeia (USP) Class VI Biological Reactivity Tests, in vivo
Problem: During protein purification processes, lipid contamination can cause an assortment of processing problems. Lipids can foul and plug expensive chromatography columns and membrane filters. Lipid contamination can also cause solution instability of intermediate and final protein products leading haze.
Solution: Our Zeta Plus™ DEL Series filter cartridges may be an option to replace bulk precipitated silica operations, which are labor-intensive and require multiple operations to implement. Zeta Plus DEL series media can be used to help remove the following lipid classes: mono-, di-, and triglycerides, fatty acids, cholesterol, phospholipids, and lipoproteins. Reduction of lipid contaminants from protein solutions may lead to improved processing economies, and improved product purity. We manufacture Zeta Plus BC Series Filter Capsules using fluid contact product components that are compliant to USP Class VI Biological Reactivity Tests.
Media Choices and Sizes:
Zeta Plus™ DEL Series Filter Cartridges are offered in sizes for applications ranging from small laboratory volumes to production-scale manufacturing operations. Filter cartridges are available in 8", 12", and 16" diameter providing effective filtration area from 0.06 m² to 3.2 m².
Applications: Lipid reduction from human blood plasma proteins such as albumin, coagulation factors, fibrinogen, and immunoglobulins, Reduction of residual lipids from serum, fermentation broths and cell culture fluids, Reduction of detergents and surfactants from biologicals and Protection of chromatographic columns and membrane filters.
The Shape of Zeta Plus Filtration:
The lenticular depth filters used in Zeta Plus filters are fabricated from two circular discs of filter media bonded along the outside rim and separated by a filtrate outlet tube at the center, which gives the disc its characteristic lens shape. Each Zeta Plus disc can then be stacked along a common exhaust manifold to produce a multicell cartridge. Several cartridges can be systematically stacked in series in larger vessels.
