Human Recombinant LIF (from E. coli)

Supplier: Peprotech

300-05-5UG 300-05-25UG 300-05-100UG 300-05-250UG 300-05-500UG 300-05-1MG

10780-422EA 141.24 USD

10780-422 10780-424 10780-426 10780-428 10780-430 10780-432

Human Recombinant LIF (from E. coli)

Proteins and Peptides

LIF is a pleiotrophic factor produced by multiple cell types, including T cells, myelomonocytic lineages, fibroblasts, liver, heart and melanoma. LIF promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Other activities include the stimulation of acute phase protein synthesis by hepatocytes, stimulation of differentiation of cholinergic nerves, and suppression of adipogenesis by inhibiting the lipoprotein lipase in adipocytes. While human LIF is active on mouse cells and is widely used in the maintenance of murine ESC to prevent spontaneous differentiation, mouse LIF is not active on human cells due to its inability to bind to the human LIF receptor. Recombinant Human LIF is a 19.6 kDa protein containing 180 amino acids residues, including three disulfide bonds.

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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