Human Recombinant Neuroserpin (from E. coli)

Supplier: Peprotech

130-14-5UG 130-14-25UG 130-14-100UG 130-14-250UG 130-14-500UG 130-14-1MG
10772-788EA 132.81 USD
10772-788 10772-790 10772-792 10772-794 10772-796 10772-798
Human Recombinant Neuroserpin (from E. coli)
Proteins and Peptides

Neuroserpin is an inhibitory serpin that is expressed predominantly in the central nervous system. Although the physiological target of neuroserpin is still unclear, cumulative evidence suggests that it plays an important role in controlling proteolytic degradation of extracellular matrix (ECM) during synaptogenesis, and the subsequent development of neuronal plasticity. In the adult brain, neuroserpin is secreted from the growth cones of neurons in areas where synaptic changes are associated with learning and memory (i.e. cerebral cortex, hippocampus, and amygdala.) The neuroprotective role of neuroserpin has been demonstrated in transgenic mice lacking neuroserpin expression. The deficiency of neuroserpin in these mice was associated with motor neuron disease characterized by axonal degradation. In humans, defects in neuroserpin, caused by point mutations in the neuroserpin gene, underlie a hereditary disorder called the familial encephalopathy with neuroserpin inclusion bodies (FENIB). Recombinant Human Neuroserpin is a 44.8 kDa non-glycosylated protein containing 395 amino acid residues.


Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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