Rat Recombinant sRANK (from E. coli)

Supplier: Peprotech

400-30-2UG 400-30-10UG 400-30-50UG 400-30-100UG 400-30-250UG 400-30-500UG 400-30-1MG
10771-032EA 132.81 USD
10771-032 10771-034 10771-036 10771-038 10771-040 10771-042 10771-044
Rat Recombinant sRANK (from E. coli)
Proteins and Peptides

RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK + T-cells, and regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant Rat sRANK Ligand is a 19.4 kDa polypeptide comprising the TNF homologous region of RANKL (174 amino acid residues).


Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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