Streptomycin sulfate, 766 IU/mg (Dry basis)
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Streptomycin Sulfate is an aminoglucoside antibiotic in which streptidine is linked glycosidically to the disaccharide streptobiosamine.
- Presentation: White Powder
- Half life: in plasma, about 2-4 hours
- Sulfated ash: 0.3%
- Loss on drying: 4.33%
Streptomycin Sulfate is used to inhibit bacterial protein synthesis at the level of initiation inhibition. It inhibits gram-negative and gram-positive bacteria.
Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation.
Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Typically used at a concentration of 50-100 mg/liter
Streptomycin Sulfate is used to inhibit bacterial protein synthesis at the level of initiation inhibition
Soluble in 4% aq soln-Clear, Colorless Solution
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Formula:
C₂₁H₃₉N₇O₁₂·1.5H₂SO₄ MW: 1457.4 g/mol Storage Temperature: Refrigerator |
MDL Number:
MFCD00037023 CAS Number: 3810-74-0 |
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Specification Test Results
| Identity Test | Passes |
| Activity | 766 IU/mg (Dry basis) |
| FTIR | Conforms to Standard |
| Loss on Drying | 4.33% |
| Solubility (4% aq soln) | Clear, Colorless Solution |
| pH | 5.8 |
| Streptomycin B | <3.0% |
| Sulfated Ash | 0.3% |
| Sulfate | 19.4% |
| Colorimetric Test | 98.2% |
| Bacterial Endotoxins | <0.25 IU/mg |
| Abnormal Toxicity | 1mg/0.5ml |
| Sterility | Passes |
| Sodium Metabisulfate | 0.012% |
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