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Description: (R,Z)-5-((2-(3-Aminopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)methylene)thiazolidine-2,4-dione, Purity: 98+%, CAS Number: 1204144-28-4, Appearance: Pale-yellow to Yellow-brown to Pale-brown Solid, Storage: Keep in dark place, Inert atmosphere, 2-8 C, Size: 1mg
Catalog Number: 77151-556
Supplier: Ambeed


Description: Potent, highly selective and orally available Pim kinase inhibitor that effectively inhibits all three isoforms Pim-1, Pim-2 and Pim-3 at <lt/>5nM or <lt/>150 nM in enzyme and cell assays, respectively. Potently inhibits colony growth and Pim signalling substrates in primary AML cells from bone marrow that are Flt3 wild-type or Flt3 internal tandem duplication mutants. Upregulation of Pim kinases is observed in several types of leukemias and lymphomas. Pim-1, -2 and -3 promote cell proliferation and survival downstream of cytokine and growth factor signaling pathways.
Catalog Number: 102992-832
Supplier: Adipogen


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