Pierce™ Pegylation Reagents, Carboxyl-PEG-Thiol Compound, Thermo Scientific
Supplier: 0000013509
Thermo Scientific Pierce CT(PEG)12 or carboxy-PEG12-thiol, is a carboxyl- and sulfhydryl-terminated compound that contains a 12-unit polyethylene glycol (PEG) spacer and is used to modify surfaces such as quantum dots, monolayers and magnetic particles.
- Provides carboxylate "handles" for protein immobilization via EDC crosslinking
- PEG groups are flexible, non-immunogenic and hydrophilic
- Terminal monodentate thiol reacts with gold surfaces through dative bonding
- Terminal carboxylic acid group allows conjugation to amine-containing affinity ligands
The use of MT(PEG)4 with CT(PEG)12 in surface modification can form a hydrophilic 'lawn' of methyl ether-terminated PEGs with periodic exposed carboxylic acid-containing PEGs. The exposed carboxylic acid groups can be coupled to affinity ligands using the carbodiimide coupling reaction with EDC and sulfo-NHS.
Caution: For Research Use Only. Not for use in diagnostic procedures.
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