GMBS (N-Succinimidyl 4-maleimidobutyrate), Pierce™

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22309
PI22309EA 247.38 USD
PI22309
GMBS (N-Succinimidyl 4-maleimidobutyrate), Pierce™
GMBS (N-Succinimidyl 4-maleimidobutyrate)

Thermo Scientific Pierce GMBS is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a short spacer arm (7.3 angstroms).


  • Reactive groups: NHS ester and maleimide
  • Reactive toward: amino and sulfhydryl groups
  • C4-homolog of aliphatic spacer series which includes AMAS, BMPS, GMBS and EMCS
  • NHS ester end couples with primary amines at pH 7-9 to form stable amide bonds
  • Maleimides react with -SH groups at pH 6.5-7.5, forming stable thioether linkages
  • Non-cleavable
  • Water-insoluble (dissolve first in DMF or DMSO); compare to Sulfo-GMBS
  • Short aliphatic spacer has low potential for eliciting an immune response


Caution: For Research Use Only. Not for use in diagnostic procedures.

Formula: C₁₂H₁₂N₂O₆
Storage Temperature: Refrigerator
MDL Number: MFCD00036817
CAS Number: 80307-12-6

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Specification Test Results

Product Line Pierce™
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Reactive Moiety Maleimide, NHS Ester
Spacer Short
Form Solid
Quantity 50 mg
Type Crosslinker
Solubility DMF, DMSO


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