Polyclonal Antibody to Absent In Melanoma 2 (AIM2), derived from recombinant AIM2(Met1~Thr343), is reactive with Human/Rat/Pig.
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AIM2 plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. AIM2 was expressed as a 39-kD protein following in vitro transcription/translation in rabbit reticulocyte lysate or transfection in a murine epithelial cell line. Cell fractionation showed that AIM2 localized primarily to the cytoplasm of transfected mouse cells.,Chromosome alterations in malignant melanoma most frequently include translocations and deletions on chromosome 1 or 6 . AIM2 encodes a deduced 344-amino acid protein that contains a conserved sequence domain of approximately 200 amino acids shared with interferon-inducible genes as well as a tyrosine kinase phosphorylation site.
Caution: For research use only. Not for use in clinical diagnostic procedures. Please proper stored each component based on the instruction.
Type: Primary
Antigen: AIM2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human;Rat;Pig