Polyclonal Antibody to Crystallin Lambda 1 (CRYl1), derived from recombinant CRYl1 (Leu24~Tyr232), is reactive with Human/Mouse.
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The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene in the rabbit is thought to serve a structural role in the lens of the eye. Human CRYL1 encodes an enzyme-crystallin with a predicted length of 319 amino acids. The protein shares 83, 84, 85, 78, and 75% sequence identity with rabbit, mouse, rat, cow, and pig lambda-crystallins. It contains 2 domains characteristic of HCDH proteins: one in the C terminus and another, an NAD-binding domain, in the N terminus. Northern blot analysis of human tissues detected ubiquitous expression of a 1.5-Kb CRYL1 transcript, at highest levels in liver and kidney. Northern blot analysis and semiquantitative RT-PCR on 60 hepatocellular carcinoma samples showed that CRYL1 was downregulated in 58% of the samples.
Caution: For research use only. Not for use in clinical diagnostic procedures. Please properly store each component based on the instruction.
Type: Primary
Antigen: CRYl1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse