Polyclonal Antibody to Interferon Alpha/Beta Receptor 2 (IFNa/bR2), derived from recombinant IFNa/bR2 (Ile27~Lys243), is reactive with Human/Mouse/Rat/Pig.
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IFNAR2 was identified by several groups, including Novick et al. (1994), Lutfalla et al. (1995), and Domanski et al. (1995). Lutfalla et al. (1995) reported the structure of the IFNAR2 gene and showed that it is located at chromosome 21q22.1 in a cluster with the class II cytokine receptor genes CRFB4 (IL10RB), IFNAR1, and AF1. They found evidence for alternative splicing of the IFNAR2 gene and showed that one of the transcripts, ifnar2-2, could functionally complement the IFN-alpha/beta receptor-defective mutant U5A cell line. Raz et al. (1995) independently reported using human-hamster somatic cell hybrids to map IFNAR2 to 21q22.1. There was no significant difference in RNA expression of the F8 and S8 IFNAR2 variants, but FACS analysis demonstrated higher cell surface expression of the F8 variant.
Caution: For research use only. Not for use in clinical diagnostic procedures. Please properly store each component based on the instruction.
Type: Primary
Antigen: IFNa/bR2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat, Pig