Anti-CYP1A1 Rabbit Polyclonal Antibody

Supplier: CLOUD-CLONE CORP MS
PAD295RA01
MSPP-PAD295RA1EA 380 USD
MSPP-PAD295RA1
Anti-CYP1A1 Rabbit Polyclonal Antibody
Antibodies
Polyclonal Antibody to Cytochrome P450 1A1 (CYP1A1), derived from recombinant CYP1A1 (Ser251~His521), is reactive with Rat.

  • High specificity, affinity, and purity
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CYP1A1 is involved in phase I xenobiotic and drug metabolism (one substrate of it is theophylline). It is inhibited by fluoroquinolones and macrolides and induced by aromatic hydrocarbons. CYP1A1 is also known as AHH (aryl hydrocarbon hydroxylase). It is involved in the metabolic activation of aromatic hydrocarbons (polycyclic aromatic hydrocarbons, PAH), for example, benzopyrene (BP), by transforming it to an epoxide. In this reaction, the oxidation of benzo[a]pyrene is catalysed by CYP1A1 to form BP-7,8-epoxide, which can be further oxidized by epoxide hydrolase (EH) to form BP-7,8-dihydrodiol. Finally CYP1A1 catalyses this intermediate to form BP-7,8-dihydrodiol-9,10-epoxide, which is the ultimate carcinogen.

Caution: For research use only. Not for use in clinical diagnostic procedures. Please properly store each component based on the instruction.

Type: Primary
Antigen: CYP1A1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Rat
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