Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 1B (LRP1B), derived from recombinant LRP1B (Leu31~Lys194), is reactive with Human/Mouse.
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LRP1B belongs to the low density lipoprotein (LDL) receptor gene family. full-length LRP1B was unstable following transfection in Lrp1 null Chinese hamster ovary (CHO) cells. In order to characterize the ligands for LRP1B, generated a minireceptor of LRP1B that could be stably expressed in CHO cells. The minireceptor began with the EGF precursor-like repeat before the fourth cluster of ligand-binding repeats (domain IV) and contained ligand-binding domain IV, the transmembrane domain, and the cytoplasmic tail. Ligands for the minireceptor, including receptor-associated protein, urokinase plasminogen activator, tissue-type plasminogen activator, and plasminogen activator inhibitor-1, were bound, internalized, and degraded via their association with the minireceptor.
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Type: Primary
Antigen: LRP1B
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human;Mouse