Anti-GREM1 Rabbit Polyclonal Antibody

Supplier: CLOUD-CLONE CORP MS
PAC128MU01
MSPP-PAC128MU1EA 360 USD
MSPP-PAC128MU1
Anti-GREM1 Rabbit Polyclonal Antibody
Antibodies
Polyclonal Antibody to Gremlin 1 (GREM1), derived from recombinant GREM1 (Lys25~Asp184), is reactive with Mouse.

  • High specificity, affinity, and purity
  • Extensive validation and batch-to-batch consistency
  • Diverse range of conjugated and custom options
  • Comprehensive validation data and documentation
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Gremlin 1 (grem 1) is known for its antagonistic reaction with bone morphogenetic proteins (BMPs) in the TGF beta signaling pathway. Grem 1 inhibits BMP-2, -4, and -7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development. Grem 1 regulation of BMP-4 in mice embryos is essential in kidney and lung branching morphogenesis. Data from microarrays of cancer and non-cancer tissues suggest that grem1 and other BMP antagonists are important in the survival of cancer stroma survival and proliferation in some cancers. Grem 1 expression is found in many cancers and is thought to play important roles in uterine cervix, lung, ovary, kidney, breast, colon, pancreas, and sarcoma carcinomas.

Caution: For research use only. Not for use in clinical diagnostic procedures. Please properly store each component based on the instruction.

Type: Primary
Antigen: GREM1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse
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