Polyclonal Antibody to Interleukin 35 (IL35), derived from recombinant IL35 (TheIL35complexcomposedofIL27Bsubunit (Arg21~Lys229)andthematureformofhumanIL12A (Arg23~Ser219)linkedbyapolypeptidelinker (GGGGS)3), is reactive with Human.
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Interleukin 35 (IL-35) is an IL-12 family cytokine that is produced by regulatory, but not effector, T cells and plays a role in immune suppression. It is a dimeric protein composed of IL-12alpha; and IL-27beta; chains, which are encoded by two separate genes called IL12A and EBI3, respectively. Secreted by regulatory T cells (Tregs), IL-35 suppresses inflammatory responses of immune cells. Studies in mice show the absence of either IL-35 chain from regulatory Tregs reduces the cells ability to suppress inflammation; this has been observed during cell culture experiments and using an experimental model for inflammatory bowel disease. To produce its suppressive effects, IL-35 has selective activities on different T cell subsets; it induces proliferation of Treg cell populations but reduces activity of Th17 cell populations.
Caution: For research use only. Not for use in clinical diagnostic procedures. Please proper stored each component based on the instruction.
Type: Primary
Antigen: IL35
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human