Polyclonal Antibody to Coagulation Factor XI (F11), derived from recombinant F11 (Pro157~Arg389), is reactive with Mouse.
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Factor XI is the zymogen form of factor XIa, one of the enzymes of the coagulation cascade. Like many other coagulation factors, it is a serine protease. Factor XI (FXI) is produced by the liver and circulates as a homo-dimer in its inactive form. The plasma half-life of FXI is approximately 52 hours. The zymogen factor is activated into factor XIa by factor XIIa (FXIIa), thrombin, and it is also autocatalytic, and FXI is a member of the 'contact pathway' due to activation by FXIIa (with includes HMWK, prekallikrein, factor XII, factor XI and factor IX). Factor XIa activates factor IX by selectively cleaving arg-ala and arg-val peptide bonds. Factor IXa, in turn, activates factor X. Inhibitors of factor XIa include protein Z-dependent protease inhibitor (ZPI), which is independent of protein Z.
Caution: For research use only. Not for use in clinical diagnostic procedures. Please properly store each component based on the instruction.
Type: Primary
Antigen: F11
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse