Anti-CYP3A2 Rabbit Polyclonal Antibody

Supplier: CLOUD-CLONE CORP MS
PAB149RA01
MSPP-PAB149RA1EA 490 USD
MSPP-PAB149RA1
Anti-CYP3A2 Rabbit Polyclonal Antibody
Antibodies
Polyclonal Antibody to Cytochrome P450 3A2 (CYP3A2), derived from recombinant CYP3A2(Met1~Asn280), is reactive with Rat.

  • High specificity, affinity, and purity
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Although rat CYP3A1 and CYP3A2 share 89% amino acid sequence similarity, they differ by 3 out of 5 of their C-terminal residues. In an effort to produce antibodies specific to each form, rabbits were immunised with the peptides IITGS and VINGA, corresponding to the C-termini of CYP3A1 and CYP3A2, respectively. Immunocytochemistry was used to determine the distribution of CYP3A1 and CYP3A2. In the liver of untreated animals, both CYP3A1 and CYP3A2 were found to be expressed in the centrilobular region. However, some CYP3A1 immunoreactivity was also detected in many, but not all, hepatocytes throughout the lobule. However, following treatment of rats with PCN, both CYP3A1 and CYP3A2 were found to be strongly expressed in hepatocytes throughout the lobule, although CYP3A2 showed greater expression in the centrilobular region.

Caution: For research use only. Not for use in clinical diagnostic procedures. Please proper stored each component based on the instruction.

Type: Primary
Antigen: CYP3A2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Rat
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